Drug-Drug Interaction Prediction & Risk Assessment

1. Report-first approach - Create DDI_risk_report.md FIRST, then populate progressively
2. Bidirectional analysis - Always analyze A→B and B→A interactions (effects may differ)
3. Evidence grading - Grade all DDI claims by evidence quality (★★★ FDA label, ★★☆ clinical study, ★☆☆ theoretical)
4. Risk scoring - Multi-dimensional scoring (0-100) combining mechanism + severity + clinical evidence
5. Patient safety focus - Provide actionable clinical guidance, not just theoretical interactions
6. Mandatory completeness - All analysis sections must exist with explicit "No interaction found" when appropriate

When to Use This Skill

• Ask about interactions between 2+ specific drugs
• Need polypharmacy risk assessment (5+ medications)
• Request medication safety review for a patient
• Ask "can I take drug X with drug Y?"
• Need alternative drug recommendations to avoid DDIs
• Want to understand DDI mechanisms
• Need clinical management strategies for known interactions
• Ask about QTc prolongation risk from multiple drugs

Critical Workflow Requirements

1. Report-First Approach (MANDATORY)

1. Create report file FIRST - Before any data collection:
   • File name:

     DDI_risk_report_[DRUG1]_[DRUG2].md

     (or

     _polypharmacy.md

     for 3+)
   • Initialize with all 9 section headers
   • Add placeholder:

     [Analyzing...]

     in each section
2. Progressively update - As data is gathered:
   • Replace

     [Analyzing...]

     with findings
   • Include "No interaction detected" when tools return empty
   • Document failed tool calls explicitly
3. Final deliverable - Complete markdown report with recommendations

Success Criteria