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Found 60 Skills
Guidance for choosing the right protein binder design tool. Use this skill when: (1) Deciding between BoltzGen, BindCraft, or RFdiffusion, (2) Planning a binder design campaign, (3) Understanding trade-offs between different approaches, (4) Selecting tools for specific target types. For specific tool parameters, use the individual tool skills (boltzgen, bindcraft, rfdiffusion, etc.).
Detect and analyze adverse drug event signals using FDA FAERS data, drug labels, disproportionality analysis (PRR, ROR, IC), and biomedical evidence. Generates quantitative safety signal scores (0-100) with evidence grading. Use for post-market surveillance, pharmacovigilance, drug safety assessment, adverse event investigation, and regulatory decision support.
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
Creates professional logical flow diagrams and logical system architecture diagrams using draw.io XML format (.drawio files). Use when creating: (1) logical flow diagrams showing data/process flow between system components, (2) logical architecture diagrams representing system structure without cloud provider specifics, (3) BPMN process diagrams, (4) UML diagrams (class, sequence, activity), (5) data flow diagrams (DFD), (6) decision flowcharts, or (7) system interaction diagrams. This skill focuses on generic/abstract representations, not AWS/Azure-specific architectures (use aws-drawio-architecture-diagrams for cloud diagrams).
Detect Single Responsibility Principle (SRP) violations using multi-dimensional analysis. Use when reviewing code for "SRP", "single responsibility", "god class", "doing too much", "too many dependencies", before commits, during refactoring, or as quality gate. Analyzes Python, JavaScript, TypeScript files with AST-based detection, metrics (TCC, ATFD, WMC), and project-specific patterns. Provides actionable fix guidance with refactoring estimates.
HOWL v2 — Hunt, Optimize, Win, Learn. Nightly self-improvement loop for the WOLF autonomous trading strategy. Runs once per day (via cron) to review all trades from the last 24 hours, compute win rates, analyze signal quality correlation, evaluate DSL tier performance, identify missed opportunities, and produce concrete improvement suggestions for the wolf-strategy skill. v2 adds fee drag ratio (FDR) analysis, holding period bucketing, LONG vs SHORT regime detection, rotation cost tracking, cumulative drift detection, and gross vs net profit factor separation. Use when setting up daily trade review automation, analyzing trading performance, or improving an autonomous trading strategy through data-driven feedback loops. Requires Senpi MCP connection, mcporter CLI, and OpenClaw cron system.
Generate Excalidraw diagrams from natural language descriptions. Outputs .excalidraw JSON files openable in Excalidraw. Use when asked to "create a diagram", "make a flowchart", "visualize a process", "draw a system architecture", "create a mind map", "generate an Excalidraw file", "draw an ER diagram", "create a sequence diagram", or "make a class diagram". Supports flowcharts, relationship diagrams, mind maps, architecture, DFD, swimlane, class, sequence, and ER diagrams. Can use icon libraries (AWS, GCP, etc.) when set up. Do NOT use for code architecture analysis (use the architecture skills), Mermaid diagram rendering (use mermaid-studio), or non-visual documentation (use docs-writer).
Use this skill when diagnosing, configuring, or monitoring NICs for AF_XDP / XDP workloads. Covers driver detection, hardware queue configuration, offload control (GSO/GRO/TSO/LRO), VLAN offloads, Flow Director (FDIR) rules, CPU core pinning and NUMA awareness, hardware queue and drop monitoring, BPF program inspection with bpftool, kernel tracing via ftrace, perf profiling and flamegraphs, IRQ-to-queue-to-core mapping, and a quick diagnostic checklist.
Use this skill when diagnosing, configuring, or monitoring NICs for AF_XDP / XDP workloads. Covers driver detection, hardware queue configuration, ring buffer sizing, RSS indirection table management, interrupt coalesce tuning, offload control (GSO/GRO/TSO/LRO), VLAN offloads, Flow Director (FDIR) rules with loc pinning and ixgbe wipe bug workaround, RPS/XPS queue CPU mapping, sysctl network tuning, CPU core pinning and NUMA awareness, hardware queue and drop monitoring, softirq and rx_missed_errors analysis, BPF program inspection with bpftool (prog dump xlated, net show), kernel tracing via ftrace and dmesg, perf profiling and flamegraphs, IRQ-to-queue-to-core mapping, bonding interface diagnostics, socket inspection, and a quick diagnostic checklist.
12 production-ready regulatory affairs and quality management skills for HealthTech/MedTech: ISO 13485 QMS, MDR 2017/745, FDA 510(k)/PMA, ISO 27001 ISMS, GDPR/DSGVO compliance, risk management (ISO 14971), CAPA, document control, and internal auditing. Python tools included (all stdlib-only). Works with Claude Code, Codex CLI, and OpenClaw.
C/C++/CAPL best practices for automotive embedded systems. This skill should be used when writing, reviewing, or refactoring embedded C/C++ code or CAPL scripts targeting automotive ECUs, following MISRA, AUTOSAR, ISO 26262, and ISO 21434 guidelines. Triggers on tasks involving embedded firmware, CAN/CAN FD/LIN/Ethernet communication, TCP/UDP/DoIP/SOME-IP protocols, RTOS programming, safety-critical code, cybersecurity, diagnostics (UDS), CAPL test automation, or calibration toolchain integration.
Structure similarity search with Foldseek. Use this skill when: (1) Finding similar structures in PDB/AFDB databases, (2) Structural homology search, (3) Database queries by 3D structure, (4) Finding remote homologs not detected by sequence, (5) Clustering structures by similarity. For sequence similarity, use uniprot BLAST. For structure prediction, use chai or boltz.