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Found 1,126 Skills
Systematic ACMG/AMP variant classification using ToolUniverse tools. Given a genetic variant (HGVS, rsID, or gene+change), applies all 28 ACMG criteria (PVS1, PS1-4, PM1-6, PP1-5, BA1, BS1-4, BP1-7) through automated database queries and computational predictions. Produces a final 5-tier classification (Pathogenic / Likely Pathogenic / VUS / Likely Benign / Benign) with evidence summary. Use when asked to classify a variant, interpret a VUS, apply ACMG criteria, assess pathogenicity, or determine clinical significance of a germline variant.
Regulatory variant interpretation -- GWAS association lookup, eQTL analysis, chromatin state annotation, regulatory element overlap, and trait ontology resolution. Connects GWAS Catalog, GTEx, ENCODE, RegulomeDB, OpenTargets, OLS ontology, and Ensembl regulatory features. Use when users ask about non-coding variants, GWAS hits, eQTLs, regulatory elements, enhancer/promoter variants, or trait-associated SNPs.
Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or analyzing variants in chr:pos:ref>alt format.
Guides hands-on actuarial analyst work for insurance, reinsurance, and pension—reserving and loss development (IBNR, triangles, chain-ladder diagnostics), pricing and rate indication support (experience, trend, credibility, basic GLM at spec level), data validation and model I/O review, reporting packs and workpapers, assumption application under actuary direction, and statutory tie-outs at analyst depth. Use when the user mentions actuarial analyst, loss development, IBNR, reserve analysis, rate indication, pricing support, actuarial workpaper, triangle analysis, credibility, experience study, actuarial reporting, or reserve roll-forward—not actuary sign-off (actuary), consulting engagements (actuarial-consulting), assumption governance (assumption-setting), ALM strategy (asset-liability-management), P&C legal depth (property-casualty-insurance), charts only (data-visualization), or ETL-only pipelines (data-scrubbing).
Guides advanced long-term actuarial mathematics (SOA ALTAM)—survival models, life insurance and annuity APVs, premiums and reserves (equivalence principle, Thiele), multiple decrement and Markov states, yield-curve discounting, mortality improvement, longevity risk, profit testing, and mortality graduation. Tool-agnostic, concept-first. Use when the user mentions advanced long-term actuarial mathematics, ALTAM, survival model, life insurance reserve, annuity valuation, equivalence principle, Thiele equation, multiple decrement, force of mortality, longevity risk, mortality improvement, actuarial present value, or net premium reserve—not ASTAM/P&C (advanced-short-term-actuarial-mathematics), workpapers only (actuarial-analyst), appointed actuary (appointed-chief-actuary), assumption governance (assumption-setting), ALM detail (asset-liability-management), or exam-only deliverables.
Guides actuarial consulting engagements—client scoping and SOW design, stakeholder communication (CFO, risk, boards, regulators at overview level), due diligence and M&A actuarial support, reserving/pricing/capital review programs, model validation and opinion support, regulatory interaction prep, and deliverable governance (memos, exhibits, management presentations). Use when the user mentions actuarial consulting, actuarial engagement, reserve opinion, due diligence actuarial, model validation engagement, actuarial memo, SOW actuarial, regulatory actuarial, M&A reserves, or actuarial review—not deep technical modeling execution (actuary), P&C line education only (property-casualty-insurance), legal advice (commercial-counsel), or generic management consulting without actuarial lens (business-consultant).
Guides advanced short-term actuarial mathematics aligned with SOA ASTAM and P&C/health-adjacent modeling—severity and frequency distributions, aggregate and compound loss models, Bühlmann and Bühlmann-Straub credibility, ratemaking and experience rating, short-term reserving at the math level, MLE and goodness-of-fit, and risk measures (VaR, TVaR). Tool-agnostic and concept-first. Use when the user mentions advanced short-term actuarial mathematics, ASTAM, severity model, frequency model, aggregate loss, compound distribution, Bühlmann credibility, experience rating, ratemaking, pure premium, negative binomial frequency, tail factor, TVaR, or short-term actuarial models—not life contingencies (life-health-insurance), Excel workpapers only (actuarial-analyst), appointed actuary sign-off (actuary, appointed-chief-actuary), assumption governance (assumption-setting), P&C legal/operations depth (property-casualty-insurance), or general ML (data-scientist, quantitative-researcher).
Adversarial robustness engineering for ML/AI—evasion, poisoning, extraction, membership-inference threat models; robust training, sanitization, detectors; ASR/certified evals; lab model attacks; data-pipeline integrity; production I/O guardrails (classical ML and LLM/multimodal). Use for adversarial examples, robustness suites, poison audits, deploy guardrails—not LLM app red team (ai-redteam), governance (ai-risk-governance), safety classifier R&D (ml-research-engineer-safeguards), safeguard serving (ml-infrastructure-engineer-safeguards), privacy research (privacy-research-engineer-safeguards), AppSec pentest (penetration-tester).
Use to attribute forecast vs actual deltas and recommend remediation actions.
Adversarial scenario analysis and threat modeling for Solidity smart contracts. Use when analyzing contracts from an attacker's perspective, identifying multi-step attack vectors, or performing threat modeling. Covers flash loan attacks, oracle manipulation, MEV/front-running, governance exploits, reentrancy scenarios, access control bypasses, economic logic exploits, and cross-contract composability risks. Triggers on tasks involving adversarial analysis, threat modeling, attack scenarios, attack vectors, exploit analysis, or red team review.
Deploy and manage projects on Vercel using token-based authentication. Use when working with Vercel CLI using access tokens rather than interactive login — e.g. "deploy to vercel", "set up vercel", "add environment variables to vercel".
Token architecture, component specifications, and slide generation. Three-layer tokens (primitive→semantic→component), CSS variables, spacing/typography scales, component specs, strategic slide creation. Use for design tokens, systematic design, brand-compliant presentations.