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Found 1,791 Skills
Analyzes genetic variant effects on gene expression (RNA-seq), chromatin accessibility (DNASE), histone marks (ChIP), and transcription factors using the AlphaGenome API. Use when the user asks about non-coding variant effects, pathogenicity, clinical significance, disease associations, functional effects, gene expression changes, splicing disruption, or regulatory effects in promoters and enhancers. Also use for resolving biological terms to tissue/cell-type ontologies (UBERON/CL) or analyzing variants in chr:pos:ref>alt format.
Post a comment (or a formal PR review) to a GitHub issue or pull request in mariadb-operator/mariadb-operator. Use whenever the user wants to publish something to GitHub for this repo — "comment on issue #123", "post this as a PR comment", "leave a note on #456", "reply on the PR" — and especially when they want the output of the mariadb-operator-pr-review skill delivered to GitHub instead of just shown in chat, e.g. "review PR #1234 and post it as a comment" or "post the review results to the PR". Always confirms the exact comment text with the user before publishing — never posts autonomously.
Use to attribute forecast vs actual deltas and recommend remediation actions.
Comprehensive structural variant (SV) analysis skill for clinical genomics. Classifies SVs (deletions, duplications, inversions, translocations), assesses pathogenicity using ACMG-adapted criteria, evaluates gene disruption and dosage sensitivity, and provides clinical interpretation with evidence grading. Use when analyzing CNVs, large deletions/duplications, chromosomal rearrangements, or any structural variants requiring clinical interpretation.
Guides advanced short-term actuarial mathematics aligned with SOA ASTAM and P&C/health-adjacent modeling—severity and frequency distributions, aggregate and compound loss models, Bühlmann and Bühlmann-Straub credibility, ratemaking and experience rating, short-term reserving at the math level, MLE and goodness-of-fit, and risk measures (VaR, TVaR). Tool-agnostic and concept-first. Use when the user mentions advanced short-term actuarial mathematics, ASTAM, severity model, frequency model, aggregate loss, compound distribution, Bühlmann credibility, experience rating, ratemaking, pure premium, negative binomial frequency, tail factor, TVaR, or short-term actuarial models—not life contingencies (life-health-insurance), Excel workpapers only (actuarial-analyst), appointed actuary sign-off (actuary, appointed-chief-actuary), assumption governance (assumption-setting), P&C legal/operations depth (property-casualty-insurance), or general ML (data-scientist, quantitative-researcher).
Fan out 50+ ad variants from one hero image.
Collect product variant data from any ecommerce page — options, colors, sizes, prices, availability. Use when the user needs variant-level data across a product.
AFK adversarial code-review loop: Cursor agent CLI critic (grug + thermo-nuclear) produces structured findings; Codex validator confirms or pushbacks on regression risk; parent adjudicates and commits fixes per finding until clean. Config at ~/.config/adversarial-review/config.toml. Use for adversarial review, clean code loop, or unattended branch hardening.
Official Framer Motion skill for animation variants — state machines, orchestrated animations, stagger, repeat, sequencing. Use when building orchestrated animations, animation state machines, staggered entrances, or when asking about Framer Motion variants, transition variants, or choreographed animations.
Audit a design proposal or diff against Exarchos's architectural invariants — event-sourcing integrity (INV-1), facade equivalence over shared dispatch core (INV-2), basileus-forward (INV-3), platform-agnosticity (INV-4), and agent-first interface design (INV-5a input ergonomics, INV-5b spec-aligned output contract, INV-5c Aspire-inspired control-plane verbs, INV-5d action discriminator pattern). Pairs with /axiom:backend-quality — this skill is project-specific (axiom is generic). Triggers: 'check invariants', 'design conformance', 'check #1118 / #1109', or /design-invariants.
Adversarial code review that assumes bugs exist and hunts for them. Use when asked to review code, find bugs, audit for correctness, stress-test a PR, or when someone says "tear this apart" or "what's wrong with this". Give no benefit of the doubt — every line is guilty until proven innocent.
Environment Variables Handler - Auto-activating skill for DevOps Basics. Triggers on: environment variables handler, environment variables handler Part of the DevOps Basics skill category.