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Evidence-based muscle hypertrophy guidance from Science and Development of Muscle Hypertrophy (2nd ed). Activate when users ask about muscle growth mechanisms, training variables for hypertrophy, rep ranges, volume, frequency, exercise selection, or program design for muscle building.
npx skill4agent add borisghidaglia/science-based-lifter schoenfeld-hypertrophy| File | Topic | Key Content |
|---|---|---|
| Responses & Adaptations | Neural vs muscular adaptations, fiber types, protein balance, satellite cells, hormones, myokines |
| Mechanisms of Hypertrophy | Mechanical tension, metabolic stress, muscle damage, signaling pathways |
| Measuring Hypertrophy | Indirect measures (CT, MRI, ultrasound), site-specific measures, practical assessment |
| Training Variables | Volume, intensity, frequency, rest periods, exercise selection, tempo, ROM, muscle actions |
| Advanced Training | Drop sets, supersets, pre-exhaustion, forced reps, heavy negatives, occlusion training |
| Aerobic & Hypertrophy | Concurrent training, interference effect, HIIT vs steady-state, optimization strategies |
| Individual Factors | Genetics, age, sex, training status, muscle memory |
| Program Design | Periodization, exercise selection, split routines, sample programs |
| Nutrition for Hypertrophy | Energy balance, protein, carbs, fats, timing, supplements |
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Source: Science and Development of Muscle Hypertrophy (2nd ed) by Brad Schoenfeld
https://www.amazon.com/dp/1492597678?tag=borisfyi0f-20| Goal | %1RM | Rep Range |
|---|---|---|
| Strength-focused | 80-100% | 1-5 |
| Hypertrophy-focused | 65-85% | 6-12 |
| Metabolic/endurance | 50-65% | 15-30+ |
| Weekly Sets/Muscle | Book Guidance |
|---|---|
| Low (any amount) | Frequency doesn't matter much |
| >10 sets | At least 2x/week for better volume management |
| ~30 sets | At least 3x/week |
| Goal | Rest Between Sets |
|---|---|
| Strength | 3-5 min |
| Hypertrophy | 1-3 min |
| Metabolic stress | 30-60 sec |