Total 50,313 skills
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Comprehensive patient stratification for precision medicine by integrating genomic, clinical, and therapeutic data. Given a disease/condition, genomic data (germline variants, somatic mutations, expression), and optional clinical parameters, performs multi-phase analysis across 9 phases covering disease disambiguation, genetic risk assessment, disease-specific molecular stratification, pharmacogenomic profiling, comorbidity/DDI risk, pathway analysis, clinical evidence and guideline mapping, clinical trial matching, and integrated outcome prediction. Generates a quantitative Precision Medicine Risk Score (0-100) with risk tier assignment (Low/Intermediate/High/Very High), treatment algorithm (1st/2nd/3rd line), pharmacogenomic guidance, clinical trial matches, and monitoring plan. Use when clinicians ask about patient risk stratification, treatment selection, prognosis prediction, or personalized therapeutic strategy across cancer, metabolic, cardiovascular, neurological, or rare diseases.
Get the latest block number for a blockchain using Web3.py and JSON-RPC environment variables
Comprehensive computational validation of drug targets for early-stage drug discovery. Evaluates targets across 10 dimensions (disambiguation, disease association, druggability, chemical matter, clinical precedent, safety, pathway context, validation evidence, structural insights, validation roadmap) using 60+ ToolUniverse tools. Produces a quantitative Target Validation Score (0-100) with GO/NO-GO recommendation. Use when users ask about target validation, druggability assessment, target prioritization, or "is X a good drug target for Y?"
Compare GWAS studies, perform meta-analyses, and assess replication across cohorts. Integrates NHGRI-EBI GWAS Catalog and Open Targets Genetics to compare study designs, effect sizes, ancestry diversity, and heterogeneity statistics. Use when comparing GWAS studies for a trait, performing meta-analysis of genetic loci, assessing replication across cohorts, or exploring the genetic architecture of complex diseases.
Use this skill when you need to write, update, migrate or fix integration tests.
QUERY LENGTH LIMIT EXCEEDED. MAX ALLOWED QUERY : 500 CHARS
Remove unwanted objects, people, text, and imperfections from photos using each::sense AI. Clean up images with intelligent inpainting that seamlessly fills removed areas.
Comprehensive multi-perspective review using specialized judges with debate and consensus building
Create and setup git worktrees for parallel development with automatic dependency installation
Custom query builders for type-safe, composable database queries. Use when working with database queries, query scoping, or when user mentions query builders, custom query builder, query objects, query scopes, database queries.
Check GitHub Actions workflow runs from the past day, identify severe or consistent failures, and file an issue if actionable problems are found.
V2 instinct-based observational learning. Analyzes sessions to extract reusable mobile development patterns across time.