Total 40,854 skills
Showing 12 of 40854 skills
Production-ready VCF processing, variant annotation, mutation analysis, and structural variant (SV/CNV) interpretation for bioinformatics questions. Parses VCF files (streaming, large files), classifies mutation types (missense, nonsense, synonymous, frameshift, splice, intronic, intergenic) and structural variants (deletions, duplications, inversions, translocations), applies VAF/depth/quality/consequence filters, annotates with ClinVar/dbSNP/gnomAD/CADD via ToolUniverse, interprets SV/CNV clinical significance using ClinGen dosage sensitivity scores, computes variant statistics, and generates reports. Solves questions like "What fraction of variants with VAF < 0.3 are missense?", "How many non-reference variants remain after filtering intronic/intergenic?", "What is the pathogenicity of this deletion affecting BRCA1?", or "Which dosage-sensitive genes overlap this CNV?". Use when processing VCF files, annotating variants, filtering by VAF/depth/consequence, classifying mutations, interpreting structural variants, assessing CNV pathogenicity, comparing cohorts, or answering variant analysis questions.
Analyze mass spectrometry proteomics data including protein quantification, differential expression, post-translational modifications (PTMs), and protein-protein interactions. Processes MaxQuant, Spectronaut, DIA-NN, and other MS platform outputs. Performs normalization, statistical analysis, pathway enrichment, and integration with transcriptomics. Use when analyzing proteomics data, comparing protein abundance between conditions, identifying PTM changes, studying protein complexes, integrating protein and RNA data, discovering protein biomarkers, or conducting quantitative proteomics experiments.
Set up GitHub Actions workflows for CI/CD with automated testing, linting, and deployment for Python/UV projects. Use when creating CI pipelines, automating tests, or setting up deployment workflows.
Joel's writing voice and style guide for joelclaw.com content. Use when writing, editing, or reviewing any blog post, essay, book chapter, or prose content for joelclaw.com. Also use when asked to 'write like Joel,' 'match Joel's voice,' 'draft a post,' 'write content for the blog,' or 'review this for voice.' This skill captures Joel's specific writing patterns derived from ~90,000 words of published content spanning 2012–2026. Cross-reference with copy-editing and copywriting skills for marketing-specific copy.
Unified command-line interface for managing feeds (Miniflux), links (Linkding), and pages (Wallabag). Use when the user wants to: save a URL as a bookmark, add or browse RSS/Atom feeds, read or search unread feed entries, save an article to Wallabag, manage tags on links or pages, or authenticate with Miniflux/Linkding/Wallabag.
Build and revise Rive Luau scripts across Node, Layout, Converter, Path Effect, Transition Condition, Listener Action, Util, and Test protocols. Use when the user asks to write or modify Rive scripts, choose protocols, wire script inputs or data binding, debug runtime behavior, or plan unit tests for script logic.
BAZDMEG Method workflow checkpoint system for AI-assisted development. Enforce quality gates at three phases: pre-code, post-code, and pre-PR. Use when: (1) starting a new feature or bug fix, (2) finishing AI-generated code before review, (3) preparing a pull request, (4) running a planning interview, (5) auditing automation readiness, (6) preventing AI slop, (7) session bootstrap, (8) source rank, (9) domain gates, (10) bugbook. Triggers: 'bazdmeg', 'pre-code checklist', 'post-code checklist', 'pre-PR checklist', 'planning interview', 'quality gates', 'session bootstrap', 'source rank', 'domain gates', 'bugbook'.
ALWAYS use when writing code importing "motion-v". Consult for debugging, best practices, or modifying motion-v, motion v, motion-vue, motion vue.
Design, refactor, and review Effector state management using modern v23+ patterns. Use when tasks involve createStore/createEvent/createEffect modeling, dataflow with sample/attach/split, scope-safe SSR with fork/allSettled/serialize/hydrate, React integration with useUnit, Solid/Vue integration patterns, fixing scope loss, or replacing anti-patterns such as business logic in watch, imperative calls in effects, and direct getState business reads.
Generate Django database migrations for Sentry. Use when creating migrations, adding/removing columns or tables, adding indexes, or resolving migration conflicts.
Best practices and usage guide for the JAW SDK (@jaw.id/core, @jaw.id/wagmi, @jaw.id/ui). Use this skill when writing code that uses jaw-sdk or @jaw.id packages, integrating JAW smart accounts into an application, configuring JAW SDK features (passkeys, permissions, gas sponsoring, ENS), building with JAW wagmi hooks, implementing headless/server-side smart account operations, debugging JAW SDK issues, or when asked about JAW SDK patterns, APIs, or best practices.
GitLab automation hub. Routes requests to specialized skills. ALWAYS use this skill when: (1) any GitLab operation, (2) unsure which skill to use, (3) multi-step GitLab workflows. Start here for any gitlab task.