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Medical Newsletter Writer

医学通讯撰写工具

Create high-quality, evidence-based medical newsletters in the style of Eric Topol's Ground Truths. This skill guides the complete newsletter creation process: from analyzing your PDF of topic ideas, to deep PubMed research, to writing in Topol's distinctive authoritative-yet-accessible voice.
创建高质量、基于循证医学的医学通讯，采用Eric Topol的Ground Truths风格。该工具指导通讯创建的完整流程：从分析您的话题想法PDF，到深入的PubMed研究，再到用Topol独特的权威且易懂的风格撰写内容。

Quick Start

快速开始

Simple 3-Step Process:
  1. Upload PDF - Upload your PDF with topic ideas in the chat
  2. Select Topic - Review engagement predictions and pick one topic
  3. Get Newsletter - Receive complete, publication-ready newsletter (~3,000 words with 20-30 PubMed citations)
The skill handles everything: PDF extraction, trend analysis, PubMed research, and writing in Eric Topol's exact voice.
简单三步流程：
  1. 上传PDF - 在聊天中上传包含话题想法的PDF文件
  2. 选择话题 - 查看参与度预测结果并挑选一个话题
  3. 获取通讯 - 收到完整的、可直接发布的通讯（约3000字，包含20-30篇PubMed引用文献）
该工具会处理所有环节：PDF提取、趋势分析、PubMed研究，以及用Eric Topol的独特风格撰写内容。

Complete Workflow

完整工作流

The newsletter creation process has 5 phases:
  1. Extract Topics from PDF - Read user's uploaded PDF of topic ideas
  2. Trend Analysis - Analyze each topic for engagement potential
  3. Topic Selection - User approves topics based on data-driven predictions
  4. Deep Research - Comprehensive PubMed literature review
  5. Newsletter Writing - Write complete newsletter in Topol's style
通讯创建流程分为5个阶段：
  1. 从PDF提取话题 - 读取用户上传的包含话题想法的PDF
  2. 趋势分析 - 分析每个话题的参与潜力
  3. 话题选择 - 用户基于数据驱动的预测结果选定话题
  4. 深入研究 - 全面的PubMed文献综述
  5. 通讯撰写 - 用Topol的风格撰写完整通讯

Phase 1: Extract Topics from PDF

第一阶段：从PDF提取话题

PDF Upload

PDF上传

User will upload a PDF containing potential newsletter topic ideas in the chat.
用户将在聊天中上传包含潜在通讯话题想法的PDF文件。

Extract Topics

提取话题

  • Read the PDF using available tools
  • Extract all topic ideas mentioned
  • Clean and organize the list
  • If PDF contains notes/context about topics, capture that too
  • 使用可用工具读取PDF
  • 提取所有提及的话题想法
  • 清理并整理列表
  • 如果PDF包含话题相关的注释/背景信息，也一并记录

Phase 2: Trend Analysis & Engagement Prediction

第二阶段：趋势分析与参与度预测

Analyze Each Topic (Automatically)

自动分析每个话题

For each topic extracted from the PDF, conduct comprehensive trend analysis:
1. News Coverage (Google News, medical news sites)
  • Search past 30 days
  • Note which outlets covering
  • Identify breaking developments
  • Count article frequency
2. Search Interest
  • Use web_search to assess current discussion
  • Look for rising interest signals
  • Note if topic is trending
3. Social Media Signals
  • YouTube: Search for videos, note view counts
  • Check if medical professionals are discussing
  • Assess virality potential
4. Academic Momentum (PubMed)
  • Count recent publications (6 months)
  • Check for major journal coverage
  • Identify ongoing trials
  • Note if field is active
针对从PDF中提取的每个话题，进行全面的趋势分析：
1. 新闻报道（Google新闻、医学新闻网站）
  • 搜索过去30天的内容
  • 记录报道该话题的媒体渠道
  • 识别突破性进展
  • 统计文章发布频率
2. 搜索热度
  • 使用网络搜索评估当前讨论热度
  • 寻找热度上升的信号
  • 记录话题是否处于趋势
3. 社交媒体信号
  • YouTube：搜索相关视频，记录播放量
  • 查看医疗专业人士是否在讨论该话题
  • 评估传播潜力
4. 学术势头（PubMed）
  • 统计近期（6个月内）的出版物数量
  • 查看是否有顶级期刊报道
  • 识别正在进行的临床试验
  • 记录该领域是否活跃

Engagement Prediction Scoring

参与度预测评分

For each topic, score 1-10 on:
  1. Readability: Can this be explained clearly to physicians?
  2. Controversy: Is there debate/opposing views?
  3. Clinical Relevance: Will this affect patient care?
  4. Timeliness: How current is this? Breaking news?
  5. Share Potential: Will physicians share with colleagues?
Overall Engagement Score = Average of 5 metrics
针对每个话题，从以下维度进行1-10分的评分：
  1. 可读性：能否向医生清晰解释该话题？
  2. 争议性：是否存在争论/对立观点？
  3. 临床相关性：是否会影响患者护理？
  4. 时效性：话题的时效性如何？是否是突发新闻？
  5. 分享潜力：医生是否会与同事分享该话题？
整体参与度评分 = 5项指标的平均值

Present Analysis

呈现分析结果

Create comparison table with:
  • Topic name
  • Brief trend summary (2-3 sentences)
  • Individual scores (1-10)
  • Overall engagement score
  • Priority recommendation (High/Medium/Low)
Sort by overall score, present top 5-10 topics to user.
创建对比表格，包含：
  • 话题名称
  • 简短趋势总结（2-3句话）
  • 各维度评分（1-10分）
  • 整体参与度评分
  • 优先级推荐（高/中/低）
按整体评分排序，向用户展示排名前5-10的话题。

Phase 3: Topic Selection

第三阶段：话题选择

Present findings to user with:
  • Top topics by engagement prediction
  • Rationale for scores
  • Notable timeliness factors
User selects ONE topic - then the skill automatically proceeds to research and writing.
向用户展示以下内容：
  • 按参与度预测排名的热门话题
  • 评分依据
  • 值得关注的时效性因素
用户选定一个话题 - 之后工具将自动进入研究和撰写环节。

Phase 4: Deep Research (Automatic)

第四阶段：自动深入研究

PubMed Search Strategy

PubMed搜索策略

Before searching, read workflow.md for detailed research guidance.
Initial searches:
  1. Broad topic overview
  2. Recent findings (<1 year)
  3. Systematic reviews/meta-analyses
  4. Major clinical trials
Paper Prioritization:
  • Tier 1: Large RCTs in NEJM, Lancet, JAMA, Science, Nature
  • Tier 2: Meta-analyses and systematic reviews
  • Tier 3: Large observational studies
  • Tier 4: Mechanistic studies in high-impact journals
  • Tier 5: Pre-clinical (use sparingly)
Target: 15-30 highly relevant papers
搜索前，请阅读workflow.md获取详细的研究指南。
初始搜索：
  1. 宽泛的话题概述
  2. 近期研究成果（<1年）
  3. 系统评价/荟萃分析
  4. 大型临床试验
论文优先级：
  • 一级：NEJM、Lancet、JAMA、Science、Nature上的大型随机对照试验（RCT）
  • 二级：荟萃分析和系统评价
  • 三级：大型观察性研究
  • 四级：高影响力期刊中的机制研究
  • 五级：临床前研究（谨慎使用）
目标： 15-30篇高度相关的论文

Extract Key Information

提取关键信息

For each major paper:
  • Study design and sample size
  • Key findings (quantitative)
  • Limitations
  • How it fits the narrative
  • Potential quotes/figures
针对每篇重要论文：
  • 研究设计和样本量
  • 关键发现（量化数据）
  • 局限性
  • 如何融入通讯叙事
  • 潜在引用内容/图表

Find Related Work

查找相关研究

  • Use PubMed related articles
  • Check major paper citations
  • Look for responses/commentary
  • Identify consensus vs. controversy
  • 使用PubMed的相关文章功能
  • 查看重要论文的引用文献
  • 寻找回应/评论
  • 识别共识与争议

Phase 5: Newsletter Writing (Automatic)

第五阶段：自动通讯撰写

Before Writing

撰写前准备

CRITICAL: Read topol-style-guide.md first - This contains essential voice patterns, phrases, and stylistic requirements.
重要提示：请先阅读topol-style-guide.md - 其中包含必要的语气模式、常用表达和格式要求。

Structure

结构

Opening (1-2 paragraphs)
  • Hook using Topol's opening patterns (see style guide)
  • Why this matters NOW
  • What will be covered
Background/Context (optional)
  • Define key terms: "To review: [term] is..."
  • Historical perspective if relevant
  • Current state of field
Main Content (3-5 sections with clear headers)
  • Each section = one major subtopic
  • Build logically
  • Include data/studies in each
  • Use tables to compare studies/treatments
  • Reference figures from papers
Implications/Future Directions
  • What this means for practice
  • Research gaps
  • What's next
Bottom Line (required)
  • Synthesize key takeaways
  • Clear conclusions based on evidence
  • Call for more evidence if needed
Standard Closing (required)
Thanks for reading and subscribing to Ground Truths.

If you found this interesting PLEASE share it!

That makes the work involved in putting these together especially worthwhile.

All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.

Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Let me know topics that you would like to see covered.
开篇（1-2段）
  • 使用Topol的开篇模式吸引读者（参考风格指南）
  • 说明该话题为何现在至关重要
  • 预告通讯涵盖的内容
背景/上下文（可选）
  • 定义关键术语：“回顾：[术语]是……”
  • 相关历史背景（如适用）
  • 该领域的当前现状
主体内容（3-5个带清晰标题的章节）
  • 每个章节对应一个主要子话题
  • 逻辑递进
  • 每个章节都包含数据/研究成果
  • 使用表格对比研究/治疗方案
  • 引用论文中的图表
意义与未来方向
  • 对临床实践的意义
  • 研究空白
  • 未来发展趋势
核心结论（必填）
  • 总结关键要点
  • 基于证据得出明确结论
  • 如有需要，呼吁更多研究证据
标准结尾（必填）
Thanks for reading and subscribing to Ground Truths.

If you found this interesting PLEASE share it!

That makes the work involved in putting these together especially worthwhile.

All content on Ground Truths—its newsletters, analyses, and podcasts, are free, open-access.

Paid subscriptions are voluntary and all proceeds from them go to support Scripps Research. They do allow for posting comments and questions, which I do my best to respond to. Please don't hesitate to post comments and give me feedback. Let me know topics that you would like to see covered.

Writing Requirements

撰写要求

Voice & Style:
  • First person engaged ("I recently fielded questions...")
  • Authoritative but accessible
  • Critical and evidence-based
  • Use Topol's signature phrases (see style guide)
Citations:
  • EVERY factual claim needs a PubMed citation with hyperlink
  • Format: link text embedded in prose
  • Cite original studies, not news articles
  • Include author names for major findings: "Professor X and colleagues at Y University published in Z..."
Critical Analysis:
  • Always discuss study limitations
  • Note conflicts of interest if relevant
  • Present alternative interpretations
  • Flag when evidence is preliminary
  • Call out hype vs. data
Length: 2,000-3,500 words
Visual Elements:
  • Create tables comparing studies/treatments
  • Describe figures from papers
  • Use clear section headers
语气与风格：
  • 使用第一人称（“我最近收到……的问题”）
  • 权威但易懂
  • 批判性且基于证据
  • 使用Topol的标志性表达（参考风格指南）
引用规范：
  • 每个事实性陈述都需要带超链接的PubMed引用
  • 格式：在正文中嵌入链接文本
  • 引用原始研究，而非新闻文章
  • 重要发现需标注作者：“X教授及其在Y大学的团队在Z期刊发表了……”
批判性分析：
  • 始终讨论研究的局限性
  • 如相关，记录利益冲突
  • 呈现不同解读
  • 标注初步证据
  • 区分炒作与数据
篇幅： 2000-3500字
视觉元素：
  • 创建表格对比研究/治疗方案
  • 描述论文中的图表
  • 使用清晰的章节标题

Quality Checks

质量检查

Before finalizing:
  • Engaging opening hook?
  • Clear why-this-matters framing?
  • Every claim cited?
  • Limitations discussed?
  • Topol's voice consistent?
  • Tables/figures included?
  • Logical flow?
  • "Bottom Line" section?
  • Standard closing?
  • 2,000-3,500 words?
定稿前需检查：
  • 开篇是否有吸引力？
  • 是否清晰说明话题的重要性？
  • 每个陈述都有引用吗？
  • 是否讨论了研究局限性？
  • 语气是否符合Topol的风格？
  • 是否包含表格/图表？
  • 逻辑流程是否通顺？
  • 是否有“核心结论”章节？
  • 是否使用标准结尾？
  • 篇幅是否在2000-3500字之间？

Delivery

交付

Final Format

最终格式

  • Complete newsletter in Markdown
  • All hyperlinked citations to PubMed
  • 2,000-3,500 words
  • Ready for user's newsletter platform
  • 完整的Markdown格式通讯
  • 所有引用均带有PubMed超链接
  • 2000-3500字
  • 可直接用于用户的通讯发布平台

Customization Note

自定义说明

User may want to change "Scripps Research" in the standard closing to their own institution/practice name.
用户可能需要将标准结尾中的“Scripps Research”替换为自己的机构/诊所名称。

Essential References

重要参考资料

ALWAYS READ BEFORE WRITING:
  • topol-style-guide.md - Complete guide to Topol's voice, phrases, patterns
  • workflow.md - Detailed research and writing process
撰写前务必阅读：
  • topol-style-guide.md - Topol语气、表达、格式要求的完整指南
  • workflow.md - 详细的研究与撰写流程

Key Success Factors

关键成功因素

  1. Evidence-based: Every claim must be cited
  2. Critical thinking: Discuss limitations, not just positives
  3. Voice consistency: Sound like Topol throughout
  4. Comprehensive: Cover topic thoroughly with multiple studies
  5. Accessible: Technical accuracy without excessive jargon
  6. Timely: Focus on recent developments
  7. Visual: Include tables/figures to enhance understanding
  8. Engaging: Hook readers immediately, maintain interest
  1. 循证性：每个陈述都必须有引用
  2. 批判性思维：讨论局限性，而非只讲优点
  3. 语气一致性：全程保持Topol的风格
  4. 全面性：用多项研究彻底覆盖话题
  5. 易懂性：技术准确但避免过多行话
  6. 时效性：聚焦近期进展
  7. 可视化：包含表格/图表提升理解
  8. 吸引力：立即抓住读者注意力，保持阅读兴趣

Example Opening Lines (Topol Style)

Topol风格示例开篇句

  • "In fielding questions recently from patients and colleagues about [topic], I was prompted to look into the field at more depth."
  • "[Term] was coined in the late [year]. Now, about [X] years later, we've yet to achieve [goal]."
  • "This week [major development] was published in [journal]. Several important reports have since been published. I've incorporated them in this updated version."
  • "There's no question that the use of [intervention] has surged, in part because of [claims], along with endorsements by [influencers]."
  • “最近在回复患者和同事关于[话题]的问题时，我决定更深入地研究该领域。”
  • “[术语]诞生于[年份]末。如今，大约[X]年过去了，我们仍未实现[目标]。”
  • “本周，[重大进展]在[期刊]上发表。此后又有多篇重要报告发布，我已将它们纳入本更新版本。”
  • “毫无疑问，[介入手段]的应用激增，部分原因是[相关宣称]以及[权威人士]的支持。”

Common Pitfalls to Avoid

需避免的常见误区

  • Don't rely on single studies - use multiple sources
  • Don't ignore study limitations - they're critical
  • Don't cherry-pick data - present full picture
  • Don't get too technical - stay accessible
  • Don't use bullet points excessively - prefer prose
  • Don't skip the critical analysis - it's essential
  • Don't forget visual elements - tables enhance understanding
  • Don't deviate from Topol's voice - consistency matters
  • 不要依赖单一研究 - 使用多个来源
  • 不要忽略研究局限性 - 这至关重要
  • 不要选择性呈现数据 - 展示完整情况
  • 不要过于技术化 - 保持易懂
  • 不要过度使用项目符号 - 优先使用段落
  • 不要跳过批判性分析 - 这是核心要求
  • 不要忘记视觉元素 - 表格能提升理解
  • 不要偏离Topol的风格 - 一致性很重要