Data Processingawslabs/hcls-agent-skills
quantitative-proteomics
Reason about quantitative proteomics experiment design and data analysis strategy. Use when the user asks to choose between LFQ, TMT, and DIA quantification; select an imputation method for missing values; pick a normalization strategy; interpret differential expression results from proteomics data; evaluate ratio compression; or design a proteomics study for biomarker discovery or validation. Triggers include "LFQ vs TMT", "DIA quantification", "proteomics normalization", "missing value imputation", "MNAR", "MinProb", "QRILC", "kNN imputation", "VSN normalization", "median centering", "quantile normalization", "limma proteomics", "ratio compression", "proteomics study design", "label-free quantification", "tandem mass tag", "data-independent acquisition", "DIA-NN", "Spectronaut", "MaxQuant LFQ", "proteomics differential expression", "empirical Bayes proteomics", "proteinGroups.txt", "MSFragger output", "TMT normalization code", "LFQ analysis", "proteomics pipeline R", "MaxQuant output".