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Found 24 Skills
Generate professional clinical decision support (CDS) documents for pharmaceutical and clinical research settings, including patient cohort analyses (biomarker-stratified with outcomes) and treatment recommendation reports (evidence-based guidelines with decision algorithms). Supports GRADE evidence grading, statistical analysis (hazard ratios, survival curves, waterfall plots), biomarker integration, and regulatory compliance. Outputs publication-ready LaTeX/PDF format optimized for drug development, clinical research, and evidence synthesis.
A decision-support framework that evaluates systems, architectures, and strategies through the entropy (decay) vs negentropy (growth) lens, while surfacing tacit knowledge gaps. Use this skill whenever the user is making architecture decisions, evaluating system designs, reviewing technical approaches, choosing between options, auditing existing systems, or planning strategies. Also trigger when the user explicitly asks to "apply the negentropy lens", mentions "entropy", "negentropy", "tacit knowledge", "knowledge engine", or "flip the switch". Nudge activation when you detect the user is at a decision point — even if they haven't asked for this lens — by briefly noting the entropic/negentropic dimension before proceeding.
Complete virtual board of directors — 28 skills covering 10 C-level roles, orchestration, cross-cutting capabilities, and culture frameworks. Features internal quality loop, two-layer memory, board meeting protocol with Phase 2 isolation, proactive triggers, and structured communication standard.
Conduct market research, competitive analysis, investor due diligence, and industry intelligence with source attribution and decision-oriented summaries. Use when the user wants market sizing, competitor comparisons, fund research, technology scans, or research that informs business decisions.
Evaluates market bubble risk through quantitative data-driven analysis using the revised Minsky/Kindleberger framework v2.1. Prioritizes objective metrics (Put/Call, VIX, margin debt, breadth, IPO data) over subjective impressions. Features strict qualitative adjustment criteria with confirmation bias prevention. Supports practical investment decisions with mandatory data collection and mechanical scoring. Use when user asks about bubble risk, valuation concerns, or profit-taking timing.
Conduct comprehensive, multi-round research that produces rich visual reports. Use when asked for "deep research", "comprehensive analysis", "compare frameworks", "evaluate options", "research the state of X", or any task requiring investigation across 10+ sources. NOT for quick lookups — this is a 5-15 minute deep dive that produces a briefing-quality artifact with screenshots, diagrams, tables, and cited findings.
Guide PMs through evaluating feature investments using revenue impact, cost structure, ROI, and strategic value. Delivers build/don't build recommendations.
Comprehensive drug-drug interaction (DDI) prediction and risk assessment. Analyzes interaction mechanisms (CYP450, transporters, pharmacodynamic), severity classification, clinical evidence grading, and provides management strategies. Supports single drug pairs, polypharmacy analysis (3+ drugs), and alternative drug recommendations. Use when users ask about drug interactions, medication safety, polypharmacy risks, or need DDI assessment for clinical decision support.
Meta-cognitive decision support that analyzes current context and surfaces intelligent next-step options to the user. Use this skill when: (1) User explicitly invokes /checkpoint, (2) Significant work has been completed and a checkpoint is valuable, (3) Uncertainty or ambiguity exists about requirements or approach, (4) Task complexity has expanded beyond initial scope, (5) Before finalizing or committing to ensure nothing is missed. This skill pauses execution, assesses the situation holistically, and presents 2-5 contextually-appropriate options via AskUserQuestion, with a recommended option and rationale.
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.
Use when you want to improve response quality through meta-cognitive reasoning. Applies 15+ reasoning methods to reconsider and refine initial outputs.