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Found 4 Skills
Use when executing oncology target-validation steps that need dependency, pharmacology, and cancer-context evidence interpreted together.
Reason about translational research problems in HCLS — especially neurology and hypothesis validation. Use when the user asks to design a validation study, evaluate a target, qualify a biomarker, choose endpoints, critique a preclinical-to-clinical plan, pick a trial design (basket/umbrella/platform), plan multimodal data integration, or assess whether a hypothesis is ready to advance. Triggers include phrases like "validate target", "biomarker context of use", "bench to bedside", "T0/T1/T2/T3/T4", "proof of mechanism", "target engagement", "design a trial for", "preclinical model translates", "imaging-genetics", "is this ready for Phase 2", "mouse results to humans", "GWAS/eQTL/MR", "endpoint selection", "drug repurposing rationale", "fail fast".
Gather comprehensive biological target intelligence from 9 parallel research paths covering protein info, structure, interactions, pathways, expression, variants, drug interactions, and literature. Features collision-aware searches, evidence grading (T1-T4), explicit Open Targets coverage, and mandatory completeness auditing. Use when users ask about drug targets, proteins, genes, or need target validation, druggability assessment, or comprehensive target profiling.
Search Open Targets drug-disease associations with natural language queries. Target validation powered by Valyu semantic search.