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Found 4 Skills
Reason about drug repurposing strategies in HCLS — choosing between target-based and phenotype-based approaches, evaluating mechanism-of-action overlap, querying drug-gene interaction databases, assessing clinical translatability, and ranking candidates by evidence strength. Use when the user asks to repurpose a drug, find approved drugs for a new indication, evaluate a repurposing candidate, query DGIdb or OpenTargets, assess drug-target interactions, design a repurposing study, rank repurposing evidence, or evaluate translatability of a candidate. Triggers include "drug repurposing", "repurpose", "repositioning", "new indication", "off-label use", "target-based repurposing", "phenotype-based repurposing", "CMap", "L1000", "DGIdb", "OpenTargets", "DrugBank", "ChEMBL", "mechanism of action overlap", "drug-gene interaction", "translatability", "existing safety data", "repurposing evidence hierarchy".
Apply structured critical thinking — identifying claims, evidence, reasoning chains, hidden assumptions, and logical fallacies — to evaluate or construct specific written arguments rigorously. Use this skill when the user presents a concrete argument, claim, op-ed, research finding, or piece of reasoning to be analyzed for logical validity or flaws, even if they say 'is this argument valid', 'what logical fallacies are in this', or 'what assumptions am I making in this thesis'. Do NOT use for casual plan review, trip planning, project risk brainstorming, or pre-mortems — 'poke holes in my plan' requests are red-team / risk review, not argument analysis.
Evaluate research rigor. Assess methodology, experimental design, statistical validity, biases, confounding, evidence quality (GRADE, Cochrane ROB), for critical analysis of scientific claims.
Structured scholarly-work evaluation for papers, proposals, literature reviews, methods sections, evidence quality, citation support, and research-writing feedback. Use when evaluating academic or scientific work — papers, proposals, methods sections, or evidence quality — against a repeatable rubric.