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Found 2,779 Skills
Provides comprehensive guidance for Spring Cloud Alibaba including Nacos, Sentinel, RocketMQ, and Alibaba Cloud integration. Use when the user asks about Spring Cloud Alibaba, needs to use Alibaba Cloud services, implement service discovery with Nacos, or work with Spring Cloud Alibaba components.
Provides AWS Lambda integration patterns for Python with cold start optimization. Use when deploying Python functions to AWS Lambda, choosing between AWS Chalice and raw Python approaches, optimizing cold starts, configuring API Gateway or ALB integration, or implementing serverless Python applications. Triggers include "create lambda python", "deploy python lambda", "chalice lambda aws", "python lambda cold start", "aws lambda python performance", "python serverless framework".
Setup Spanora AI observability in any project (JavaScript/TypeScript or Python). Use when user asks to "add spanora", "setup spanora", "integrate spanora", "add AI observability", "monitor LLM calls with spanora", "track AI costs", or mentions spanora in the context of adding observability to their project. Detects the language and installed AI SDKs (Vercel AI, Anthropic, OpenAI, LangChain) and configures the optimal integration pattern.
Analyze metabolomics data including metabolite identification, quantification, pathway analysis, and metabolic flux. Processes LC-MS, GC-MS, NMR data from targeted and untargeted experiments. Performs normalization, statistical analysis, pathway enrichment, metabolite-enzyme integration, and biomarker discovery. Use when analyzing metabolomics datasets, identifying differential metabolites, studying metabolic pathways, integrating with transcriptomics/proteomics, discovering metabolic biomarkers, performing flux balance analysis, or characterizing metabolic phenotypes in disease, drug response, or physiological conditions.
Architectural reference for WorkOS AuthKit integrations. Fetch README first for implementation details.
Analyze spatial transcriptomics data to map gene expression in tissue architecture. Supports 10x Visium, MERFISH, seqFISH, Slide-seq, and imaging-based platforms. Performs spatial clustering, domain identification, cell-cell proximity analysis, spatial gene expression patterns, tissue architecture mapping, and integration with single-cell data. Use when analyzing spatial transcriptomics datasets, studying tissue organization, identifying spatial expression patterns, mapping cell-cell interactions in tissue context, characterizing tumor microenvironment spatial structure, or integrating spatial and single-cell RNA-seq data for comprehensive tissue analysis.
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.
Integrate and analyze multiple omics datasets (transcriptomics, proteomics, epigenomics, genomics, metabolomics) for systems biology and precision medicine. Performs cross-omics correlation, multi-omics clustering (MOFA+, NMF), pathway-level integration, and sample matching. Coordinates ToolUniverse skills for expression data (RNA-seq), epigenomics (methylation, ChIP-seq), variants (SNVs, CNVs), protein interactions, and pathway enrichment. Use when analyzing multi-omics datasets, performing integrative analysis, discovering multi-omics biomarkers, studying disease mechanisms across molecular layers, or conducting systems biology research that requires coordinated analysis of transcriptome, genome, epigenome, proteome, and metabolome data.
Analyze mass spectrometry proteomics data including protein quantification, differential expression, post-translational modifications (PTMs), and protein-protein interactions. Processes MaxQuant, Spectronaut, DIA-NN, and other MS platform outputs. Performs normalization, statistical analysis, pathway enrichment, and integration with transcriptomics. Use when analyzing proteomics data, comparing protein abundance between conditions, identifying PTM changes, studying protein complexes, integrating protein and RNA data, discovering protein biomarkers, or conducting quantitative proteomics experiments.
Design, refactor, and review Effector state management using modern v23+ patterns. Use when tasks involve createStore/createEvent/createEffect modeling, dataflow with sample/attach/split, scope-safe SSR with fork/allSettled/serialize/hydrate, React integration with useUnit, Solid/Vue integration patterns, fixing scope loss, or replacing anti-patterns such as business logic in watch, imperative calls in effects, and direct getState business reads.
Apple HIG guidance for Apple technology integrations: Siri, Apple Pay, HealthKit, HomeKit, ARKit, machine learning, generative AI, iCloud, Sign in with Apple, SharePlay, CarPlay, Game Center, in-app purchase, NFC, Wallet, VoiceOver, Maps, Mac Catalyst, and more. Use when asked about: "Siri integration", "Apple Pay", "HealthKit", "HomeKit", "ARKit", "augmented reality", "machine learning", "generative AI", "iCloud sync", "Sign in with Apple", "SharePlay", "CarPlay", "in-app purchase", "NFC", "VoiceOver", "Maps", "Mac Catalyst". Also use when the user says "how do I integrate Siri," "what are the Apple Pay guidelines," "how should my AR experience work," "how do I use Sign in with Apple," or asks about any Apple framework or service integration. Cross-references: hig-inputs for input methods, hig-components-system for widgets.
Use this skill when you need to write, update, migrate or fix integration tests.