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Found 1,060 Skills
Comprehensive patient stratification for precision medicine by integrating genomic, clinical, and therapeutic data. Given a disease/condition, genomic data (germline variants, somatic mutations, expression), and optional clinical parameters, performs multi-phase analysis across 9 phases covering disease disambiguation, genetic risk assessment, disease-specific molecular stratification, pharmacogenomic profiling, comorbidity/DDI risk, pathway analysis, clinical evidence and guideline mapping, clinical trial matching, and integrated outcome prediction. Generates a quantitative Precision Medicine Risk Score (0-100) with risk tier assignment (Low/Intermediate/High/Very High), treatment algorithm (1st/2nd/3rd line), pharmacogenomic guidance, clinical trial matches, and monitoring plan. Use when clinicians ask about patient risk stratification, treatment selection, prognosis prediction, or personalized therapeutic strategy across cancer, metabolic, cardiovascular, neurological, or rare diseases.
CLI for debugging Node.js backend processes with non-blocking inspection. Use when the user needs to connect to Node.js processes (by PID, name, Docker, or port), set tracepoints/logpoints/exceptionpoints, capture call stacks and local variables, run JavaScript in the process context, or inspect console logs. Requires daemon; connect before other debug commands.
Configure and operate BiomeJS in JavaScript/TypeScript projects, including installation, `biome.json` setup, formatter/linter/check workflows, VCS integration, and CI usage. Use when users ask to adopt Biome, tune rules/includes, set up monorepo/shared configs, or troubleshoot Biome command behavior.
Finds all REFACTOR markers in codebase, validates associated ADRs exist, identifies stale markers (30+ days old), and detects orphaned markers (no ADR reference). Use during status checks, before feature completion, or for refactor health audits. Triggers on "check refactor status", "marker health", "what's the status", or PROACTIVELY before marking features complete. Works with Python (.py), TypeScript (.ts), and JavaScript (.js) files using grep patterns to locate markers and validate against ADR files in docs/adr/ directories.
Evidence-based test debugging enforcing systematic root cause analysis. Use when tests are failing, pytest errors occur, test suite not passing, debugging test failures, or fixing broken tests. Prevents assumption-based fixes by enforcing proper diagnostic sequence. Works with Python (.py), JavaScript/TypeScript (.js/.ts), Go, Rust test files. Supports pytest, jest, vitest, mocha, go test, cargo test, and other frameworks.
Detect Single Responsibility Principle (SRP) violations using multi-dimensional analysis. Use when reviewing code for "SRP", "single responsibility", "god class", "doing too much", "too many dependencies", before commits, during refactoring, or as quality gate. Analyzes Python, JavaScript, TypeScript files with AST-based detection, metrics (TCC, ATFD, WMC), and project-specific patterns. Provides actionable fix guidance with refactoring estimates.
TypeScript, React, and JavaScript best practices enforced by Ultracite/Biome.
Create and manage PNPM workspaces following Constructive standards. Use when asked to "create a monorepo", "set up a workspace", "configure pnpm", or when starting a new TypeScript/JavaScript project with multiple packages.
Automate Adobe After Effects via ExtendScript. Use when the user asks to create, modify, or query anything in an After Effects project — layers, keyframes, expressions, effects, compositions, assets, rendering, batch operations. Generates and executes JSX ExtendScript via osascript on macOS.
Analyze CVE vulnerabilities in Java and JavaScript components, determine false positives, and provide upgrade recommendations. Use this when users provide a CVE number and affected object, e.g., CVE-2024-38816 and spring-webmvc-5.3.39.jar. Supports false positive analysis, compatibility risk assessment, and standard report generation.
Skill for creating custom lint rules by leveraging the existing linter ecosystems of various programming languages. This is a linter designed for AI Agents rather than humans, and its error messages function as correction instruction prompts for AI. Create custom rules in the `lints/` directory using standard methods for each language, including Rust (dylint), TypeScript/JavaScript (ESLint), Python (pylint), Go (golangci-lint), etc. Use this skill in the following scenarios: (1) When you want AI to enforce project-specific coding rules; (2) When you want to create lint rules that output AI-readable correction instructions when violations occur; (3) When you want to enforce naming conventions, structural patterns, and consistency rules through AI-driven linting. Triggers: "Create a linter rule", "Add a lint rule", "Enforce this pattern", "AI linter", "Custom lint", "Code rules", "Naming rules", "Structural rules", "create a linter rule", "add a lint rule", "enforce this pattern", "AI linter".
Modernize JavaScript/TypeScript toolchain to high-performance native alternatives. Use when upgrading build tools, linters, or compilers.