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Found 139 Skills
Expert blueprint for performance profiling and optimization (frame drops, memory leaks, draw calls) using Godot Profiler, object pooling, visibility culling, and bottleneck identification. Use when diagnosing lag, optimizing for target FPS, or reducing memory usage. Keywords profiling, Godot Profiler, bottleneck, object pooling, VisibleOnScreenNotifier, draw calls, MultiMesh.
Expert knowledge of Godot performance optimization, profiling, bottleneck identification, and optimization techniques. Use when helping improve game performance or analyzing performance issues.
Comprehensive chemical safety and toxicology assessment integrating ADMET-AI predictions, CTD toxicogenomics, FDA label safety data, DrugBank safety profiles, and STITCH chemical-protein interactions. Performs predictive toxicology (AMES, DILI, LD50, carcinogenicity), organ/system toxicity profiling, chemical-gene-disease relationship mapping, regulatory safety extraction, and environmental hazard assessment. Use when asked about chemical toxicity, drug safety profiling, ADMET properties, environmental health risks, chemical hazard assessment, or toxicogenomic analysis.
Comprehensive epigenomics and gene regulation analysis integrating ENCODE functional genomics data, JASPAR transcription factor binding motifs, SCREEN cis-regulatory elements, ReMap TF binding sites, RegulomeDB variant regulatory scoring, 4D Nucleome chromatin conformation, and Ensembl regulatory features. Performs regulatory element cataloging, transcription factor analysis, variant regulatory impact scoring, chromatin conformation mapping, and gene-centric regulatory landscape profiling. Use when asked about gene regulation, enhancers, promoters, transcription factor binding, epigenetic modifications, chromatin structure, regulatory variants, or non-coding genome function.
Psychological profiling through natural conversation using narrative identity research (McAdams), self-defining memory elicitation (Singer), and Motivational Interviewing (OARS framework). Use when you need to: (1) understand someone's core values and motivations, (2) discover formative memories and life-defining experiences, (3) detect emotional schemas and belief patterns, (4) build psychological profiles through gradual disclosure, (5) conduct user interviews that reveal deep insights, (6) design conversational flows for personal discovery, (7) identify identity themes like redemption and contamination narratives, (8) elicit authentic self-disclosure without interrogation.
Systematically investigates, diagnoses, and resolves complex Magento 2 technical problems. Use when debugging issues, investigating bugs, analyzing performance problems, resolving errors, or troubleshooting system failures. Masters log analysis, performance profiling, and root cause analysis.
Comprehensive immune repertoire analysis for T-cell and B-cell receptor sequencing data. Analyze TCR/BCR repertoires to assess clonality, diversity, V(D)J gene usage, CDR3 characteristics, convergence, and predict epitope specificity. Integrate with single-cell data for clonotype-phenotype associations. Use for adaptive immune response profiling, cancer immunotherapy research, vaccine response assessment, autoimmune disease studies, or repertoire diversity analysis in immunology research.
Comprehensive patient stratification for precision medicine by integrating genomic, clinical, and therapeutic data. Given a disease/condition, genomic data (germline variants, somatic mutations, expression), and optional clinical parameters, performs multi-phase analysis across 9 phases covering disease disambiguation, genetic risk assessment, disease-specific molecular stratification, pharmacogenomic profiling, comorbidity/DDI risk, pathway analysis, clinical evidence and guideline mapping, clinical trial matching, and integrated outcome prediction. Generates a quantitative Precision Medicine Risk Score (0-100) with risk tier assignment (Low/Intermediate/High/Very High), treatment algorithm (1st/2nd/3rd line), pharmacogenomic guidance, clinical trial matches, and monitoring plan. Use when clinicians ask about patient risk stratification, treatment selection, prognosis prediction, or personalized therapeutic strategy across cancer, metabolic, cardiovascular, neurological, or rare diseases.
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.
heaptrack memory profiler skill for Linux. Use when tracking heap allocations, finding memory leaks, measuring peak heap usage, identifying allocation hotspots, or comparing allocation behaviour between runs. Activates on queries about heaptrack, heap profiling, memory allocation analysis, heaptrack_print, allocation hotspots, or memory leak detection with heaptrack.
Optimize application performance and scalability. Use when investigating slow applications, scaling bottlenecks, or improving response times. Use for profiling, caching, database optimization, frontend performance, and backend tuning.
Optimizes ClickHouse queries for speed and efficiency. Helps with primary key design, sparse indexes, data skipping indexes (minmax, set, bloom filter, ngrambf_v1), partitioning strategies, projections, PREWHERE optimization, approximate functions, and query profiling with EXPLAIN. Use when writing ClickHouse queries, designing table schemas, analyzing slow queries, or implementing analytical aggregations. Works with columnar OLAP workloads.