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Found 305 Skills
Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.
Differential gene expression analysis (Python DESeq2). Identify DE genes from bulk RNA-seq counts, Wald tests, FDR correction, volcano/MA plots, for RNA-seq analysis.
Deep generative models for single-cell omics. Use when you need probabilistic batch correction (scVI), transfer learning, differential expression with uncertainty, or multi-modal integration (TOTALVI, MultiVI). Best for advanced modeling, batch effects, multimodal data. For standard analysis pipelines use scanpy.
Query the CELLxGENE Census (61M+ cells) programmatically. Use when you need expression data across tissues, diseases, or cell types from the largest curated single-cell atlas. Best for population-scale queries, reference atlas comparisons. For analyzing your own data use scanpy or scvi-tools.
Standard single-cell RNA-seq analysis pipeline. Use for QC, normalization, dimensionality reduction (PCA/UMAP/t-SNE), clustering, differential expression, and visualization. Best for exploratory scRNA-seq analysis with established workflows. For deep learning models use scvi-tools; for data format questions use anndata.
Automatically detects and documents user preferences, coding rules, and style guidelines when expressed during conversations
Run nf-core bioinformatics pipelines (rnaseq, sarek, atacseq) on sequencing data. Use when analyzing RNA-seq, WGS/WES, or ATAC-seq data—either local FASTQs or public datasets from GEO/SRA. Triggers on nf-core, Nextflow, FASTQ analysis, variant calling, gene expression, differential expression, GEO reanalysis, GSE/GSM/SRR accessions, or samplesheet creation.
Forces exhaustive problem-solving using corporate PUA rhetoric and structured debugging methodology. MUST trigger when: (1) any task has failed 2+ times or you're stuck in a loop tweaking the same approach; (2) you're about to say 'I cannot', suggest the user do something manually, or blame the environment without verifying; (3) you catch yourself being passive — not searching, not reading source, not verifying, just waiting for instructions; (4) user expresses frustration in ANY form: 'try harder', 'stop giving up', 'figure it out', 'why isn't this working', 'again???', '换个方法', '为什么还不行', '你再试试', '加油', '你怎么又失败了', or any similar sentiment even if phrased differently. Also trigger when facing complex multi-step debugging, environment issues, config problems, or deployment failures where giving up early is tempting. Applies to ALL task types: code, config, research, writing, deployment, infrastructure, API integration. Do NOT trigger on first-attempt failures or when a known fix is already executing successfully.
Use when implementing deformation effects, bounce animations, impact responses, or any motion requiring organic elasticity and weight expression.
Use when defining brand motion identity, creating animation guidelines for brand expression, or aligning animation with brand personality.
LaTeX academic paper assistant for English papers (IEEE, ACM, Springer, NeurIPS, ICML). Domains: Deep Learning, Time Series, Industrial Control. Triggers (use ANY module independently): - "compile", "编译", "build latex" → Compilation Module - "format check", "chktex", "格式检查" → Format Check Module - "grammar", "语法", "proofread", "润色" → Grammar Analysis Module - "long sentence", "长句", "simplify" → Long Sentence Analysis Module - "academic tone", "学术表达", "improve writing" → Expression Module - "logic", "coherence", "methodology", "argument structure", "论证" → Logical Coherence & Methodological Depth Module - "translate", "翻译", "中译英", "Chinese to English" → Translation Module - "bib", "bibliography", "参考文献" → Bibliography Module - "deai", "去AI化", "humanize", "reduce AI traces" → De-AI Editing Module - "title", "标题", "title optimization", "create title" → Title Optimization Module
Find which of a GitHub repository's dependencies are sponsorable via GitHub Sponsors. Uses deps.dev API for dependency resolution across npm, PyPI, Cargo, Go, RubyGems, Maven, and NuGet. Checks npm funding metadata, FUNDING.yml files, and web search. Verifies every link. Shows direct and transitive dependencies with OSSF Scorecard health data. Invoke with /sponsor followed by a GitHub owner/repo (e.g. "/sponsor expressjs/express").