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Found 457 Skills
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
Evaluate creative work against explicit taste preferences. Use when drafting to align with project aesthetics, when reviewing to surface preference conflicts, or when generating voting options to reflect diverse tastes.
This skill should be used when the user asks to "ask questions interactively", "use the question tool", "present choices to the user", "avoid yes/no prompts", "use interactive confirmations", or needs guidance on asking structured questions with selectable options instead of free-text prompts.
Weighted decision scoring framework for architectural and technology choices. Frames decisions with 2-4 options, scores against weighted criteria, detects close calls, and records decisions in the active ADR or task plan. Use when: "should I use X or Y", "which approach", "compare options", "trade-offs between", "help me decide", "evaluate alternatives"
Apply the Business Model Canvas (BMC) to map and evaluate business models across nine building blocks. Use this skill when the user needs to design a new business model, evaluate an existing one, compare business model options, or prepare for a strategy session — even if they say 'describe our business model', 'how do we make money', 'fill out a BMC', or 'design a new revenue model'.
Use this skill when rendering thousands of lightweight sprites in PixiJS v8. Covers ParticleContainer with Particle instances, addParticle/removeParticle, particleChildren array, dynamicProperties (vertex, position, rotation, uvs, color), boundsArea, roundPixels, update. Triggers on: ParticleContainer, Particle, IParticle, addParticle, particleChildren, dynamicProperties, boundsArea, particle effects, constructor options, ParticleContainerOptions, ParticleOptions.
Use this skill when adding screen reader and keyboard navigation to PixiJS v8 apps. Covers AccessibilitySystem options (enabledByDefault, debug, activateOnTab, deactivateOnMouseMove), per-container accessibility properties, shadow DOM overlay, mobile touch-hook activation. Triggers on: accessibility, a11y, screen reader, ARIA, keyboard navigation, tab order, AccessibilitySystem, accessibleTitle, accessibleHint, tabIndex, accessibleChildren.
Use this skill when displaying animated GIFs in PixiJS v8. Covers the pixi.js/gif side-effect import, Assets.load returning a GifSource, GifSprite playback (play/stop/currentFrame/animationSpeed), autoPlay/loop options, onComplete/onLoop/onFrameChange callbacks, GifSource sharing, clone, destroy. Triggers on: GifSprite, GifSource, pixi.js/gif, animationSpeed, currentFrame, autoPlay, onComplete, onFrameChange, constructor options, GifSpriteOptions.
Use this skill when overlaying HTML elements on the PixiJS v8 canvas. Covers DOMContainer with element, anchor, and scene-graph-driven CSS transforms, the pixi.js/dom side-effect import, DOMPipe registration, visibility sync, pointer-events handling. Triggers on: DOMContainer, pixi.js/dom, DOMPipe, HTML overlay, input on canvas, iframe overlay, DOMContainerOptions, element, anchor, constructor options.
Use this skill when upgrading to PixiJS v8 from v7 or diagnosing broken v7 code after an upgrade. Covers async app.init, single pixi.js package (deprecated @pixi/* sub-packages), Graphics shape-then-fill, BaseTexture → TextureSource, shader/uniform rework, ParticleContainer+Particle, constructor options objects, DisplayObject removal, settings/utils removal, Ticker signature, events rewrite. Triggers on: migrate v7, v8 breaking changes, @pixi/ import, DisplayObject, beginFill, endFill, cacheAsBitmap, BaseTexture, deprecated.
Implement Syncfusion Blazor Input components including FileUpload, TextBox, NumericTextBox, TextArea, Signature, RangeSlider, OtpInput, Rating, InputMask, and ColorPicker. Use this when working with file uploads, text entry, numeric values, multi-line text inputs, signatures, ratings, or color selection. This skill covers input validation, events, data binding, and advanced customization options for all input-related components in Blazor applications.
Download videos from YouTube and other platforms for offline viewing, editing, or archival with support for various formats and quality options.