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Found 5,141 Skills
Perform comprehensive gene enrichment and pathway analysis using gseapy (ORA and GSEA), PANTHER, STRING, Reactome, and 40+ ToolUniverse tools. Supports GO enrichment (BP, MF, CC), KEGG, Reactome, WikiPathways, MSigDB Hallmark, and 220+ Enrichr libraries. Handles multiple ID types (gene symbols, Ensembl, Entrez, UniProt), multiple organisms (human, mouse, rat, fly, worm, yeast), customizable backgrounds, and multiple testing correction (BH, Bonferroni). Use when users ask about gene enrichment, pathway analysis, GO term enrichment, KEGG pathway analysis, GSEA, over-representation analysis, functional annotation, or gene set analysis.
AI-driven patient-to-trial matching for precision medicine and oncology. Given a patient profile (disease, molecular alterations, stage, prior treatments), discovers and ranks clinical trials from ClinicalTrials.gov using multi-dimensional matching across molecular eligibility, clinical criteria, drug-biomarker alignment, evidence strength, and geographic feasibility. Produces a quantitative Trial Match Score (0-100) per trial with tiered recommendations and a comprehensive markdown report. Use when oncologists, molecular tumor boards, or patients ask about clinical trial options for specific cancer types, biomarker profiles, or post-progression scenarios.
Generate custom sticker designs using each::sense AI. Create die-cut stickers, vinyl decals, kawaii designs, brand logos, emoji packs, laptop stickers, bumper stickers, planner stickers, holographic effects, and complete sticker sheets.
Force critical evaluation of proposals, requirements, or decisions by analyzing from multiple adversarial perspectives. Triggers on: accepting a proposal without pushback, 'sounds good', 'let's go with', design decisions with unstated tradeoffs, unchallenged assumptions, premature consensus. Invoke with /challenge-that.
Generate hologram and 3D display content using each::sense AI. Create holographic product displays, presenters, 3D logos, interactive menus, event content, museum exhibits, retail displays, and trade show holograms.
Best practices, coding conventions, and patterns for backend projects using TypeScript. Use when writing code, tests, or new features in TypeScript backends with src/, Express, PostgreSQL/MongoDB, and Mocha+tsx.
Comprehensive patient stratification for precision medicine by integrating genomic, clinical, and therapeutic data. Given a disease/condition, genomic data (germline variants, somatic mutations, expression), and optional clinical parameters, performs multi-phase analysis across 9 phases covering disease disambiguation, genetic risk assessment, disease-specific molecular stratification, pharmacogenomic profiling, comorbidity/DDI risk, pathway analysis, clinical evidence and guideline mapping, clinical trial matching, and integrated outcome prediction. Generates a quantitative Precision Medicine Risk Score (0-100) with risk tier assignment (Low/Intermediate/High/Very High), treatment algorithm (1st/2nd/3rd line), pharmacogenomic guidance, clinical trial matches, and monitoring plan. Use when clinicians ask about patient risk stratification, treatment selection, prognosis prediction, or personalized therapeutic strategy across cancer, metabolic, cardiovascular, neurological, or rare diseases.
Comprehensive computational validation of drug targets for early-stage drug discovery. Evaluates targets across 10 dimensions (disambiguation, disease association, druggability, chemical matter, clinical precedent, safety, pathway context, validation evidence, structural insights, validation roadmap) using 60+ ToolUniverse tools. Produces a quantitative Target Validation Score (0-100) with GO/NO-GO recommendation. Use when users ask about target validation, druggability assessment, target prioritization, or "is X a good drug target for Y?"
Production-ready RNA-seq differential expression analysis using PyDESeq2. Performs DESeq2 normalization, dispersion estimation, Wald testing, LFC shrinkage, and result filtering. Handles multi-factor designs, multiple contrasts, batch effects, and integrates with gene enrichment (gseapy) and ToolUniverse annotation tools (UniProt, Ensembl, OpenTargets). Supports CSV/TSV/H5AD input formats and any organism. Use when analyzing RNA-seq count matrices, identifying DEGs, performing differential expression with statistical rigor, or answering questions about gene expression changes.
Bytecode interpreter and JIT compiler skill for implementing language runtimes in C/C++. Use when designing bytecode dispatch loops (switch, computed goto, threaded code), implementing stack-based or register-based VMs, adding a simple JIT using mmap/mprotect, or understanding performance trade-offs in interpreter design. Activates on queries about bytecode VMs, dispatch loops, computed goto, JIT compilation basics, tracing JITs, or implementing a scripting language runtime.
Titanium SDK official fundamentals and configuration guide. Use when working with, reviewing, analyzing, or examining Titanium projects, Hyperloop native access, app distribution (App Store/Google Play), tiapp.xml configuration, CLI commands, memory management, bridge optimization, CommonJS modules, SQLite transactions, or coding standards. Applies to both Alloy and Classic projects.
Advanced SOQL skill with natural language to query generation, query optimization, relationship traversal, aggregate functions, and performance analysis. Build efficient queries that respect governor limits and security requirements.