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Found 352 Skills
OAuth 2.0 and OpenID Connect authentication with secure flows. Use for third-party integrations, SSO systems, token-based API access, or encountering authorization code flow, PKCE, token refresh, scope management errors.
This skill is used when users request phrases such as 'handle PR review issues', 'fix review items', 'resolve PR feedback', 'process review issues one by one', 'complete review tasks', 'run pr review resolver', 'resolve PR review', 'address review comments', 'fix review findings', or 'handle code review'. It reads the review comments of the PR associated with the current branch, discusses each unresolved issue with the user one by one, lets the user decide on the handling approach, and executes fixes in parallel as background subtasks.
Expert patterns for HubSpot CRM integration including OAuth authentication, CRM objects, associations, batch operations, webhooks, and custom objects. Covers Node.js and Python SDKs. Use when: hubspot, hubspot api, hubspot crm, hubspot integration, contacts api.
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
Integrate Cartridge Controller into native mobile applications (iOS, Android, React Native) and web wrappers (Capacitor). Use when building mobile games or apps that need Controller wallet functionality with local keypair signing. Covers SessionConnector for native auth flows, Controller.c FFI bindings, passkey configuration with Apple App Site Association, and platform-specific setup.
Comprehensive immune repertoire analysis for T-cell and B-cell receptor sequencing data. Analyze TCR/BCR repertoires to assess clonality, diversity, V(D)J gene usage, CDR3 characteristics, convergence, and predict epitope specificity. Integrate with single-cell data for clonotype-phenotype associations. Use for adaptive immune response profiling, cancer immunotherapy research, vaccine response assessment, autoimmune disease studies, or repertoire diversity analysis in immunology research.
Interpret genetic variants (SNPs) from GWAS studies by aggregating evidence from multiple databases (GWAS Catalog, Open Targets Genetics, ClinVar). Retrieves variant annotations, GWAS trait associations, fine-mapping evidence, locus-to-gene predictions, and clinical significance. Use when asked to interpret a SNP by rsID, find disease associations for a variant, assess clinical significance, or answer questions like "What diseases is rs429358 associated with?" or "Interpret rs7903146".
Discover genes associated with diseases and traits using GWAS data from the GWAS Catalog (500,000+ associations) and Open Targets Genetics (L2G predictions). Identifies genetic risk factors, prioritizes causal genes via locus-to-gene scoring, and assesses druggability. Use when asked to find genes associated with a disease or trait, discover genetic risk factors, translate GWAS signals to gene targets, or answer questions like "What genes are associated with type 2 diabetes?"
Comprehensive computational validation of drug targets for early-stage drug discovery. Evaluates targets across 10 dimensions (disambiguation, disease association, druggability, chemical matter, clinical precedent, safety, pathway context, validation evidence, structural insights, validation roadmap) using 60+ ToolUniverse tools. Produces a quantitative Target Validation Score (0-100) with GO/NO-GO recommendation. Use when users ask about target validation, druggability assessment, target prioritization, or "is X a good drug target for Y?"
Transform GWAS signals into actionable drug targets and repurposing opportunities. Performs locus-to-gene mapping, target druggability assessment, existing drug identification, safety profile evaluation, and clinical trial matching. Use when discovering drug targets from GWAS data, finding drug repurposing opportunities from genetic associations, or translating GWAS findings into therapeutic leads.
GCC compiler skill for C/C++ projects. Use when selecting optimization levels, warning flags, debug builds, LTO, sanitizer instrumentation, or diagnosing compilation errors with GCC. Covers flag selection for debug vs release, ABI concerns, preprocessor macros, profile-guided optimization, and integration with build systems. Activates on queries about gcc flags, compilation errors, performance tuning, warning suppression, or cross-standard compilation.
Proactively summarize and consolidate knowledge from AI conversation sessions. Auto-triggers when: (1) Starting a new session after meaningful previous work, (2) Session contains significant learnings worth preserving. Captures debugging insights, architecture decisions, patterns, configs, and lessons learned into structured knowledge documents. Explicit triggers: 'summarize', 'consolidate', 'save knowledge', 'document this'.