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Found 752 Skills
Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Aggregates evidence from ClinVar, gnomAD, CIViC, UniProt, and PDB across ACMG criteria. Produces pathogenicity scores (0-100), clinical recommendations, and treatment implications. Use when interpreting genetic variants, classifying variants of uncertain significance (VUS), performing ACMG variant classification, or translating variant calls to clinical actionability.
Production-ready VCF processing, variant annotation, mutation analysis, and structural variant (SV/CNV) interpretation for bioinformatics questions. Parses VCF files (streaming, large files), classifies mutation types (missense, nonsense, synonymous, frameshift, splice, intronic, intergenic) and structural variants (deletions, duplications, inversions, translocations), applies VAF/depth/quality/consequence filters, annotates with ClinVar/dbSNP/gnomAD/CADD via ToolUniverse, interprets SV/CNV clinical significance using ClinGen dosage sensitivity scores, computes variant statistics, and generates reports. Solves questions like "What fraction of variants with VAF < 0.3 are missense?", "How many non-reference variants remain after filtering intronic/intergenic?", "What is the pathogenicity of this deletion affecting BRCA1?", or "Which dosage-sensitive genes overlap this CNV?". Use when processing VCF files, annotating variants, filtering by VAF/depth/consequence, classifying mutations, interpreting structural variants, assessing CNV pathogenicity, comparing cohorts, or answering variant analysis questions.
Adversarial code review using the opposite model. Spawns 1–3 reviewers on the opposing model (Claude spawns Codex, Codex spawns Claude) to challenge work from distinct critical lenses. Triggers: "adversarial review".
Aria Attribute Helper - Auto-activating skill for Frontend Development. Triggers on: aria attribute helper, aria attribute helper Part of the Frontend Development skill category.
Devil's Advocate stress-testing for code, architecture, PRs, and decisions. Surfaces hidden flaws through structured adversarial analysis with metacognitive depth. Use for high-stakes review, stress-testing choices, or when the user wants problems found deliberately. NOT for routine code review (use engineering:code-review). Triggers on "스트레스 테스트", "stress test", "devil's advocate", "반론", "이거 괜찮아", "문제 없을까", "깊은 리뷰", "critical review", "adversarial".
Perform a Cynical Review and produce a findings report. Use when the user requests a critical review of something
Perses variable lifecycle management: create Text and List variables at global, project, or dashboard scope. Handle variable chains with dependencies (A depends on B depends on C). Supports 14+ interpolation formats. Uses MCP tools when available, percli CLI as fallback. Use for "perses variable", "dashboard variable", "perses filter", "add variable". Do NOT use for datasource management (use perses-datasource-manage).
7 Email 1 variations from ColdIQ core framework plus Email 2 and Email 3 templates. Use when crafting the first email in a sequence, testing different opening structures, or building complete email cadences.
Use to attribute forecast vs actual deltas and recommend remediation actions.
Adversarial scenario analysis and threat modeling for Solidity smart contracts. Use when analyzing contracts from an attacker's perspective, identifying multi-step attack vectors, or performing threat modeling. Covers flash loan attacks, oracle manipulation, MEV/front-running, governance exploits, reentrancy scenarios, access control bypasses, economic logic exploits, and cross-contract composability risks. Triggers on tasks involving adversarial analysis, threat modeling, attack scenarios, attack vectors, exploit analysis, or red team review.
Environment Variables Handler - Auto-activating skill for DevOps Basics. Triggers on: environment variables handler, environment variables handler Part of the DevOps Basics skill category.
Review code through hostile perspectives to find bugs, security issues, and unintended consequences the author missed. Use when reviewing PRs, auditing codebases, or before critical deployments.