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Found 3,500 Skills
Force critical evaluation of proposals, requirements, or decisions by analyzing from multiple adversarial perspectives. Triggers on: accepting a proposal without pushback, 'sounds good', 'let's go with', design decisions with unstated tradeoffs, unchallenged assumptions, premature consensus. Invoke with /challenge-that.
Best practices, coding conventions, and patterns for backend projects using TypeScript. Use when writing code, tests, or new features in TypeScript backends with src/, Express, PostgreSQL/MongoDB, and Mocha+tsx.
Comprehensive patient stratification for precision medicine by integrating genomic, clinical, and therapeutic data. Given a disease/condition, genomic data (germline variants, somatic mutations, expression), and optional clinical parameters, performs multi-phase analysis across 9 phases covering disease disambiguation, genetic risk assessment, disease-specific molecular stratification, pharmacogenomic profiling, comorbidity/DDI risk, pathway analysis, clinical evidence and guideline mapping, clinical trial matching, and integrated outcome prediction. Generates a quantitative Precision Medicine Risk Score (0-100) with risk tier assignment (Low/Intermediate/High/Very High), treatment algorithm (1st/2nd/3rd line), pharmacogenomic guidance, clinical trial matches, and monitoring plan. Use when clinicians ask about patient risk stratification, treatment selection, prognosis prediction, or personalized therapeutic strategy across cancer, metabolic, cardiovascular, neurological, or rare diseases.
Comprehensive computational validation of drug targets for early-stage drug discovery. Evaluates targets across 10 dimensions (disambiguation, disease association, druggability, chemical matter, clinical precedent, safety, pathway context, validation evidence, structural insights, validation roadmap) using 60+ ToolUniverse tools. Produces a quantitative Target Validation Score (0-100) with GO/NO-GO recommendation. Use when users ask about target validation, druggability assessment, target prioritization, or "is X a good drug target for Y?"
Titanium SDK official fundamentals and configuration guide. Use when working with, reviewing, analyzing, or examining Titanium projects, Hyperloop native access, app distribution (App Store/Google Play), tiapp.xml configuration, CLI commands, memory management, bridge optimization, CommonJS modules, SQLite transactions, or coding standards. Applies to both Alloy and Classic projects.
Guide for using direnv - a shell extension for loading directory-specific environment variables. Use when setting up project environments, creating .envrc files, configuring per-project environment variables, integrating with Python/Node/Ruby/Go layouts, working with Nix flakes, or troubleshooting environment loading issues on macOS and Linux.
Generate project status reports from Jira issues and publish to Confluence. When Claude needs to: (1) Create a status report for a project, (2) Summarize project progress or updates, (3) Generate weekly/daily reports from Jira, (4) Publish status summaries to Confluence, or (5) Analyze project blockers and completion. Queries Jira issues, categorizes by status/priority, and creates formatted reports for delivery managers and executives.
Disaster recovery drill exercises and security checklists for web application projects (SPA, SSR, full-stack web apps). Focused on solo/indie developers using free-tier infrastructure (Vercel, Supabase, Cloudflare, Netlify, Railway, etc.). Bridges big-tech best practices (NIST, Google SRE DiRT, ISO 22301) to indie scale. Use when the user mentions drills, disaster recovery, security audit, incident simulation, project health check, resilience testing, backup strategies, secret rotation, or incident response for web projects. Not for mobile apps, desktop software, CLI tools, or games.
Custom training plans by goal (strength, cardio, flexibility). Progressive overload programming, rest day optimization, home vs gym adaptations, deload weeks.
Create viral philosophical social media posts using proven psychological patterns and narrative structures. Generates posts in three archetypes (Patient Observer, Dramatic Prophet, Quiet Devastator). Use when the user wants to write social media posts, tweets, philosophical content, viral posts, or wisdom-style content. Triggers on "write a viral post", "create social media content", "write a tweet about...", "philosophical post", or "help me write posts that go viral".
DeFi legos and protocol composability on Ethereum and L2s. Major protocols per chain — Aerodrome on Base, GMX/Pendle on Arbitrum, Velodrome on Optimism — plus mainnet primitives (Uniswap, Aave, Compound, Curve). How they work, how to build on them, and how to combine them. Use when building DeFi integrations, choosing protocols on a specific L2, designing yield strategies, or composing existing protocols into something new.
Evaluate every produced output (code, report, plan, data, API response) against type-specific quality criteria, score 1-10, make accept/reject decisions, and provide actionable improvement suggestions. Triggers on "evaluate", "check", "review", "quality control", "is this good enough", "score it", or before passing output to the next step in an agentic workflow.