Loading...
Loading...
Found 223 Skills
When user asks about "confidence", "accuracy", "how sure", "uncertain", "reliable", "track record", or when Claude should express calibrated uncertainty. Enables domain-aware self-assessment.
Detect and remove AI-generated expression patterns in articles, used for writing polishing, text optimization, and eliminating AI-style phrasing.
Production-ready RNA-seq differential expression analysis using PyDESeq2. Performs DESeq2 normalization, dispersion estimation, Wald testing, LFC shrinkage, and result filtering. Handles multi-factor designs, multiple contrasts, batch effects, and integrates with gene enrichment (gseapy) and ToolUniverse annotation tools (UniProt, Ensembl, OpenTargets). Supports CSV/TSV/H5AD input formats and any organism. Use when analyzing RNA-seq count matrices, identifying DEGs, performing differential expression with statistical rigor, or answering questions about gene expression changes.
Backend architecture patterns, API design, database optimization, and server-side best practices for Node.js, Express, and Next.js API routes.
Computational analysis framework for spatial multi-omics data integration. Given spatially variable genes (SVGs), spatial domain annotations, tissue type, and disease context from spatial transcriptomics/proteomics experiments (10x Visium, MERFISH, DBiTplus, SLIDE-seq, etc.), performs comprehensive biological interpretation including pathway enrichment, cell-cell interaction inference, druggable target identification, immune microenvironment characterization, and multi-modal integration. Produces a detailed markdown report with Spatial Omics Integration Score (0-100), domain-by-domain characterization, and validation recommendations. Uses 70+ ToolUniverse tools across 9 analysis phases. Use when users ask about spatial transcriptomics analysis, spatial omics interpretation, tissue heterogeneity, spatial gene expression patterns, tumor microenvironment mapping, tissue zonation, or cell-cell communication from spatial data.
Applies Material Design 3 Expressive dynamic color and theming principles to user interfaces. Use this when working on color palettes, themes, dynamic color systems, accessibility, or when the user asks to apply Material Design 3 color guidelines to a design or application.
Applies Material Design 3 Expressive typography principles including variable fonts, type scales, and hierarchy. Use this when working on text styling, type hierarchy, readable interfaces, or when the user asks to apply Material Design 3 typography guidelines.
Use when ANY runtime debugging is needed — setting breakpoints, inspecting variables, evaluating expressions, analyzing threads, or reproducing crashes interactively with LLDB
API testing patterns with supertest, MSW, and Vitest. Covers integration testing for REST APIs, HTTP request mocking with Mock Service Worker v2, response assertions, schema validation, test organization, and framework-specific patterns for Express, Fastify, and Hono. Use when writing integration tests for REST APIs, mocking HTTP requests, or testing API endpoints. Use for api-test, supertest, msw, mock-service-worker, integration-test, http-mock, endpoint-test, request-test.
Analyze existing brand content to extract voice patterns, create voice guidelines, and ensure consistent brand expression
Node.js backend patterns: framework selection, layered architecture, TypeScript, validation, error handling, security, production deployment. Use when building REST APIs, Express/Fastify servers, microservices, or server-side TypeScript.
Creates visual design philosophies and expresses them as static art in PNG and PDF formats using composition, color theory, typography, and graphic design principles. Use when asked to "create a poster", "design artwork", "make a visual design", "create static art", or "design a graphic piece". Develops aesthetic movements through form, space, color, and minimal text as visual accents. Works with PDF and PNG output files plus markdown design manifestos. Produces original visual designs using design philosophy methodology rather than copying existing artists.