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Found 2,622 Skills
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.
Integrate and analyze multiple omics datasets (transcriptomics, proteomics, epigenomics, genomics, metabolomics) for systems biology and precision medicine. Performs cross-omics correlation, multi-omics clustering (MOFA+, NMF), pathway-level integration, and sample matching. Coordinates ToolUniverse skills for expression data (RNA-seq), epigenomics (methylation, ChIP-seq), variants (SNVs, CNVs), protein interactions, and pathway enrichment. Use when analyzing multi-omics datasets, performing integrative analysis, discovering multi-omics biomarkers, studying disease mechanisms across molecular layers, or conducting systems biology research that requires coordinated analysis of transcriptome, genome, epigenome, proteome, and metabolome data.
Analyze mass spectrometry proteomics data including protein quantification, differential expression, post-translational modifications (PTMs), and protein-protein interactions. Processes MaxQuant, Spectronaut, DIA-NN, and other MS platform outputs. Performs normalization, statistical analysis, pathway enrichment, and integration with transcriptomics. Use when analyzing proteomics data, comparing protein abundance between conditions, identifying PTM changes, studying protein complexes, integrating protein and RNA data, discovering protein biomarkers, or conducting quantitative proteomics experiments.
Design, refactor, and review Effector state management using modern v23+ patterns. Use when tasks involve createStore/createEvent/createEffect modeling, dataflow with sample/attach/split, scope-safe SSR with fork/allSettled/serialize/hydrate, React integration with useUnit, Solid/Vue integration patterns, fixing scope loss, or replacing anti-patterns such as business logic in watch, imperative calls in effects, and direct getState business reads.
Apple HIG guidance for Apple technology integrations: Siri, Apple Pay, HealthKit, HomeKit, ARKit, machine learning, generative AI, iCloud, Sign in with Apple, SharePlay, CarPlay, Game Center, in-app purchase, NFC, Wallet, VoiceOver, Maps, Mac Catalyst, and more. Use when asked about: "Siri integration", "Apple Pay", "HealthKit", "HomeKit", "ARKit", "augmented reality", "machine learning", "generative AI", "iCloud sync", "Sign in with Apple", "SharePlay", "CarPlay", "in-app purchase", "NFC", "VoiceOver", "Maps", "Mac Catalyst". Also use when the user says "how do I integrate Siri," "what are the Apple Pay guidelines," "how should my AR experience work," "how do I use Sign in with Apple," or asks about any Apple framework or service integration. Cross-references: hig-inputs for input methods, hig-components-system for widgets.
Use this skill when you need to write, update, migrate or fix integration tests.
Create and use brand.yml files for consistent branding across Shiny apps and Quarto documents. Use when working with brand styling, colors, fonts, logos, or corporate identity in Shiny or Quarto projects. Covers: (1) Creating new _brand.yml files from brand guidelines, (2) Applying brand.yml to Shiny for R apps with bslib, (3) Applying brand.yml to Shiny for Python apps with ui.Theme, (4) Using brand.yml in Quarto documents, presentations, dashboards, and PDFs, (5) Modifying existing brand.yml files, (6) Troubleshooting brand integration issues. Includes complete specifications and framework-specific integration guides.
Service layer for external API integration using manager pattern and Saloon. Use when working with external APIs, third-party services, or when user mentions services, external API, Saloon, API integration, manager pattern.
Complete Metaplex Protocol guide for Solana NFTs and digital assets. Covers Core (next-gen NFTs), Token Metadata, Bubblegum (compressed NFTs), Candy Machine, Genesis (token launches), MPL-Hybrid, Inscriptions, DAS API, and the Umi framework. The single source of truth for all Metaplex integrations.
Unified prompt engineering and requirements planning. Use when exploring ideas, improving prompts, creating PRDs, generating task breakdowns, or iterating on existing plans. Includes Jira integration for creating subtasks from plans.
Configure enterprise SSO, role-based access control, and organization management. Use when implementing SSO integration, configuring role-based permissions, or setting up organization-level controls. Trigger with phrases like "clerk SSO", "clerk RBAC", "clerk enterprise", "clerk roles", "clerk permissions", "clerk SAML".
Publish documentation and books with GitBook including spaces, collections, variants, Git sync, collaboration, and API integration