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Found 255 Skills
Discover genes associated with diseases and traits using GWAS data from the GWAS Catalog (500,000+ associations) and Open Targets Genetics (L2G predictions). Identifies genetic risk factors, prioritizes causal genes via locus-to-gene scoring, and assesses druggability. Use when asked to find genes associated with a disease or trait, discover genetic risk factors, translate GWAS signals to gene targets, or answer questions like "What genes are associated with type 2 diabetes?"
Comprehensive computational validation of drug targets for early-stage drug discovery. Evaluates targets across 10 dimensions (disambiguation, disease association, druggability, chemical matter, clinical precedent, safety, pathway context, validation evidence, structural insights, validation roadmap) using 60+ ToolUniverse tools. Produces a quantitative Target Validation Score (0-100) with GO/NO-GO recommendation. Use when users ask about target validation, druggability assessment, target prioritization, or "is X a good drug target for Y?"
Provides Better Auth authentication integration patterns for NestJS backend and Next.js frontend with Drizzle ORM and PostgreSQL. Use when implementing authentication - Setting up Better Auth with NestJS backend, Integrating Next.js App Router frontend, Configuring Drizzle ORM schema with PostgreSQL, Implementing social login (GitHub, Google, etc.), Adding plugins (2FA, Organization, SSO, Magic Link, Passkey), Email/password authentication with session management, Creating protected routes and middleware
Rapid Symfony admin panel development with EasyAdminBundle. Capabilities: CRUD generation, dashboard creation, entity management, form customization, menu configuration, field configuration, action customization, filters, permissions, batch actions, custom themes, file uploads, image handling, associations, submenus, custom queries, event listeners. Use for: admin panels, backend interfaces, content management, data administration, CRUD operations, user management, product catalogs, blog administration, e-commerce backends. Triggers: easyadmin, symfony admin, crud, admin panel, dashboard, backend, entity crud, admin interface, symfony backend, easyadmin, easyadmin bundle, admin generator, backend panel
Proactively summarize and consolidate knowledge from AI conversation sessions. Auto-triggers when: (1) Starting a new session after meaningful previous work, (2) Session contains significant learnings worth preserving. Captures debugging insights, architecture decisions, patterns, configs, and lessons learned into structured knowledge documents. Explicit triggers: 'summarize', 'consolidate', 'save knowledge', 'document this'.
Finds all REFACTOR markers in codebase, validates associated ADRs exist, identifies stale markers (30+ days old), and detects orphaned markers (no ADR reference). Use during status checks, before feature completion, or for refactor health audits. Triggers on "check refactor status", "marker health", "what's the status", or PROACTIVELY before marking features complete. Works with Python (.py), TypeScript (.ts), and JavaScript (.js) files using grep patterns to locate markers and validate against ADR files in docs/adr/ directories.
Vite build tool configuration and ecosystem. Covers vite.config.ts setup, plugin authoring and popular plugins, dev server configuration (proxy, HMR, HTTPS), build optimization (chunking, tree-shaking, manual chunks, rollupOptions), library mode for publishing packages, SSR configuration, environment variables (.env handling), multi-page apps, CSS handling (PostCSS, CSS modules, preprocessors), and asset handling. Use when configuring Vite projects, authoring Vite plugins, optimizing builds, setting up dev server proxies, configuring SSR, handling environment variables, or troubleshooting Vite issues.
Identify, assess, and mitigate operational risks. Trigger with "what are the risks", "risk assessment", "risk register", "what could go wrong", or when the user is evaluating risks associated with a project, vendor, process, or decision.
VectorBT backtesting expert. Use when user asks to backtest strategies, create entry/exit signals, analyze portfolio performance, optimize parameters, fetch historical data, use VectorBT/vectorbt, compare strategies, position sizing, equity curves, drawdown charts, or trade analysis. Also triggers for openalgo.ta helpers (exrem, crossover, crossunder, flip, donchian, supertrend).
Expert children's book writer creating delightful, engaging books for ages 2-9. Specializes in rhyming books, stories, songs with proper values, educational content, and age-appropriate language. Crafts books that captivate young readers while teaching important life lessons.
Payment gateway development in Bagisto. Activates when creating payment methods, integrating payment gateways like Stripe, PayPal, or any third-party payment processor; or when the user mentions payment, payment gateway, payment method, Stripe, PayPal, or needs to add a new payment option to the checkout.
Deprecated legacy TalkToMePy TTS skill retained for backward compatibility. Prefer successor speech workflows in [gaelic-ghost/a11y-skills](https://github.com/gaelic-ghost/a11y-skills).