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Found 223 Skills
This skill is to be used when users request in-depth analysis, thorough thinking, or detailed breakdown of a problem. It is triggered by expressions such as: 'Help me think deeply', 'Please analyze carefully', 'Help me break it down in detail', 'Please organize my thoughts', 'Think carefully', 'Gain in-depth understanding', 'Analyze in detail', or similar phrases indicating a need for systematic thinking. This skill adopts the ReAct-Plan framework: integrating chain-of-thought reasoning with explicit global planning, dynamic prediction, and reflection to overcome short-sighted behaviors.
Quality control metrics and filtering thresholds for protein design. Use this skill when: (1) Evaluating design quality for binding, expression, or structure, (2) Setting filtering thresholds for pLDDT, ipTM, PAE, (3) Checking sequence liabilities (cysteines, deamidation, polybasic clusters), (4) Creating multi-stage filtering pipelines, (5) Computing PyRosetta interface metrics (dG, SC, dSASA), (6) Checking biophysical properties (instability, GRAVY, pI), (7) Ranking designs with composite scoring. This skill provides research-backed thresholds from binder design competitions and published benchmarks.
Guidance for cell-free protein synthesis (CFPS) optimization. Use when: (1) Planning CFPS experiments, (2) Troubleshooting low yield or aggregation, (3) Optimizing DNA template design for CFPS, (4) Expressing difficult proteins (disulfide-rich, toxic, membrane).
Solubility-optimized protein sequence design using SolubleMPNN. Use this skill when: (1) Designing for E. coli expression, (2) Optimizing solubility of designed proteins, (3) Reducing aggregation propensity, (4) Need high-yield expression, (5) Avoiding inclusion body formation. For standard design, use proteinmpnn. For ligand-aware design, use ligandmpnn.
Design protein sequences using ProteinMPNN inverse folding. Use this skill when: (1) Designing sequences for RFdiffusion backbones, (2) Redesigning existing protein sequences, (3) Fixing specific residues while designing others, (4) Optimizing sequences for expression or stability, (5) Multi-state or negative design. For backbone generation, use rfdiffusion or bindcraft. For ligand-aware design, use ligandmpnn. For solubility optimization, use solublempnn.
NestJS 11+ best practices for enterprise Node.js applications with TypeScript. Use when writing, reviewing, or refactoring NestJS controllers, services, modules, or APIs. Triggers on: NestJS modules, controllers, providers, dependency injection, @Injectable, @Controller, @Module, middleware, guards, interceptors, pipes, exception filters, ValidationPipe, class-validator, class-transformer, DTOs, JWT authentication, Passport strategies, @nestjs/passport, TypeORM entities, Prisma client, Drizzle ORM, repository pattern, circular dependencies, forwardRef, @nestjs/swagger, OpenAPI decorators, GraphQL resolvers, @nestjs/graphql, microservices, TCP transport, Redis transport, NATS, Kafka, NestJS 11 breaking changes, Express v5 migration, custom decorators, ConfigService, @nestjs/config, health checks, or NestJS testing patterns.
Comprehensive DeepResearch methodology for conducting rigorous, traceable research projects with quality gates, structured analysis, and decision-ready deliverables. Use when (1) Conducting deep research projects requiring evidence-based analysis, (2) Managing research progress with quality gates and artifacts, (3) Producing research reports with traceable sources and structured reasoning, (4) Applying OSINT verification techniques, (5) Using structured analytic techniques (ACH, Key Assumptions Check, Red Team), (6) Expressing uncertainty and confidence in research findings, (7) Ensuring research deliverables meet intelligence tradecraft standards (ICD 203/206/208)
Converts long inline XAML bindings to Property Element Syntax for better readability. Use when XAML binding expressions become too long or complex.
Integrate crypto payments into any web application with PayRam. Self-hosted payment gateway — no KYC, no signup, no third-party custody. Accept USDT, USDC, Bitcoin, ETH in under 10 minutes. Works with Express, Next.js, FastAPI, Laravel, Gin, Spring Boot. Drop-in replacement for Stripe/PayPal for crypto. Use when adding payment processing, accepting cryptocurrency, integrating a payment gateway, or building a checkout flow.
Debug Node.js/TypeScript/JavaScript applications using the agent-dbg CLI debugger. Use when: (1) investigating runtime bugs by stepping through code, (2) inspecting variable values at specific execution points, (3) setting breakpoints and conditional breakpoints, (4) evaluating expressions in a paused context, (5) hot-patching code without restarting, (6) debugging test failures by attaching to a running process, (7) any task where understanding runtime behavior requires a debugger. Triggers: "debug this", "set a breakpoint", "step through", "inspect variables", "why is this value wrong", "trace execution", "attach debugger", "runtime error".
Perl text processing and scripting with regular expressions. Use for .pl files.
Fiber Express-inspired Go web framework. Use for Go APIs.