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Found 1,718 Skills
Analyzes and optimizes SQL queries for performance. Use for index design, query rewriting, EXPLAIN/EXPLAIN ANALYZE interpretation, PostgreSQL tuning, N+1 prevention, CTE and window function optimization, join strategies, and common SQL anti-patterns.
Systematic ACMG/AMP variant classification using ToolUniverse tools. Given a genetic variant (HGVS, rsID, or gene+change), applies all 28 ACMG criteria (PVS1, PS1-4, PM1-6, PP1-5, BA1, BS1-4, BP1-7) through automated database queries and computational predictions. Produces a final 5-tier classification (Pathogenic / Likely Pathogenic / VUS / Likely Benign / Benign) with evidence summary. Use when asked to classify a variant, interpret a VUS, apply ACMG criteria, assess pathogenicity, or determine clinical significance of a germline variant.
Population genetics research using the 1000 Genomes Project (IGSR) -- search populations by superpopulation ancestry (AFR, AMR, EAS, EUR, SAS), retrieve samples by population code, list available data collections, and integrate with GWAS tools for population stratification analysis. Use when users ask about 1000 Genomes populations, sample ancestry, allele frequency variation across continental groups, population-specific GWAS interpretation, or IGSR data collections like the 30x high-coverage resequencing or HGSVC.
Analyze HLA genes, MHC binding, epitope-MHC associations, and immunogenomics for transplant compatibility, vaccine design, and immunotherapy. Integrates IMGT, IEDB, BVBRC, UniProt, and DGIdb. Use for HLA typing interpretation, antigen presentation analysis, MHC restriction, neoantigen prediction context, and transplant immunology.
Guide pharmacogenomics (PGx) research -- drug-gene interaction lookup, CPIC guideline retrieval, variant-drug annotation, allele function status, FDA biomarker labeling, and clinical dosing recommendations. Covers the full CPIC-to-PharmGKB-to-clinical-recommendation workflow. Use when users ask about pharmacogenomics, drug-gene interactions, CPIC guidelines, genotype-guided dosing, PGx biomarkers, CYP enzyme phenotypes, or star allele interpretation.
Regulatory variant interpretation -- GWAS association lookup, eQTL analysis, chromatin state annotation, regulatory element overlap, and trait ontology resolution. Connects GWAS Catalog, GTEx, ENCODE, RegulomeDB, OpenTargets, OLS ontology, and Ensembl regulatory features. Use when users ask about non-coding variants, GWAS hits, eQTLs, regulatory elements, enhancer/promoter variants, or trait-associated SNPs.
Core technical-indicator signal engine for stocks listed in HK / US / A-share / Singapore via Longbridge Securities. Computes and interprets MACD, KDJ, RSI, Bollinger Bands, EMA, ADX, and OBV from OHLCV data; combines multi-dimensional votes (trend / mean-reversion / volume-price) to produce a composite buy / sell / neutral signal. Triggers: "技术指标", "MACD", "KDJ", "RSI", "布林带", "布林线", "EMA", "ADX", "OBV", "金叉", "死叉", "超买", "超卖", "技术分析", "趋势指标", "量价", "技術指標", "布林帶", "技術分析", "超買", "超賣", "technical indicator", "MACD signal", "KDJ overbought", "RSI oversold", "Bollinger Bands", "moving average", "golden cross", "death cross", "technical analysis".
Designing lead magnets that earn the email. The discipline of building gated content (ebooks, templates, checklists, swipe files, mini-courses, free tools) that delivers genuine standalone value while qualifying the lead and warming them for what comes next. Honest about thin-bait (overpromises, underdelivers), kitchen-sink-resource (everything, helps with nothing), and earned-value-magnet (delivers standalone value while qualifying the lead). Triggers on lead magnet, gated content, opt-in offer, ebook, checklist, template, swipe file, mini-course, free tool, content upgrade, freebie, opt-in, list-building offer. Also triggers when an audience is being asked for an email and the offer attached to that ask needs design discipline, when previous lead magnets converted but did not produce qualified leads, or when a lead magnet is being scoped for the first time.
Plan and run a multi-language or multi-region site. Use this skill when adding new locales, choosing URL structure for languages (subfolders vs subdomains vs ccTLDs), implementing hreflang, planning translation workflow, handling currency and date formats, designing for RTL languages, or auditing a stalled internationalization rollout. Triggers on internationalization, i18n, localization, l10n, hreflang, multi-language, translation workflow, RTL, locale, ccTLD, subfolder vs subdomain, language switcher. Also triggers when international audiences underperform or translations are stale.
Run conversion rate optimization through hypothesis-driven testing including audit, hypothesis generation, test design, statistical analysis, and rollout decisions. Use this skill whenever the user wants to optimize conversion, run A/B tests, audit a funnel, generate test hypotheses, design experiments, or analyze test results. Triggers on conversion optimization, CRO, A/B test, split test, multivariate test, hypothesis, conversion funnel, funnel audit, experiment design, statistical significance, lift, optimization. Also triggers when the user has a conversion problem and isn't sure where to start, or when test results are ambiguous and need interpretation.
Professional, brand-aligned design with structured grids, minimalist layouts, and consistent enterprise patterns.
Helps DevOps engineers configure mirrord Operator's Kafka queue splitting feature end-to-end. Generates MirrordKafkaClientConfig and MirrordKafkaTopicsConsumer Kubernetes CRD YAMLs, the matching mirrord.json split_queues section, and Helm value guidance. Use this skill whenever the user mentions Kafka splitting with mirrord, MirrordKafkaClientConfig, MirrordKafkaTopicsConsumer, Kafka queue splitting, Kafka topic splitting, configuring mirrord with Kafka, setting up Kafka for mirrord operator, or troubleshooting Kafka splitting sessions. Also trigger when users mention split_queues with queue_type Kafka, or ask about connecting mirrord to a Kafka cluster. This is a Team/Enterprise feature of mirrord.