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Found 758 Skills
Analyzes code for WCAG 2.4.4 Link Purpose (In Context) compliance. Identifies generic link text, ambiguous links, and links without sufficient context. Recommends descriptive link text and proper ARIA attributes.
Comprehensive epigenomics and gene regulation analysis integrating ENCODE functional genomics data, JASPAR transcription factor binding motifs, SCREEN cis-regulatory elements, ReMap TF binding sites, RegulomeDB variant regulatory scoring, 4D Nucleome chromatin conformation, and Ensembl regulatory features. Performs regulatory element cataloging, transcription factor analysis, variant regulatory impact scoring, chromatin conformation mapping, and gene-centric regulatory landscape profiling. Use when asked about gene regulation, enhancers, promoters, transcription factor binding, epigenetic modifications, chromatin structure, regulatory variants, or non-coding genome function.
Environment variables and parameters for running command line programs reliably in non-interactive environments (unattended). Includes silent modes, color/disable TTY, and reduced output options for 155 CLI tools.
Force critical evaluation of proposals, requirements, or decisions by analyzing from multiple adversarial perspectives. Triggers on: accepting a proposal without pushback, 'sounds good', 'let's go with', design decisions with unstated tradeoffs, unchallenged assumptions, premature consensus. Invoke with /challenge-that.
Interpret genetic variants (SNPs) from GWAS studies by aggregating evidence from multiple databases (GWAS Catalog, Open Targets Genetics, ClinVar). Retrieves variant annotations, GWAS trait associations, fine-mapping evidence, locus-to-gene predictions, and clinical significance. Use when asked to interpret a SNP by rsID, find disease associations for a variant, assess clinical significance, or answer questions like "What diseases is rs429358 associated with?" or "Interpret rs7903146".
Get the latest block number for a blockchain using Web3.py and JSON-RPC environment variables
Identify and prioritize causal variants at GWAS loci using statistical fine-mapping and locus-to-gene predictions. Computes posterior probabilities for causal variants, links variants to genes via L2G predictions, annotates functional consequences, and suggests validation strategies. Use when asked to fine-map GWAS loci, prioritize causal variants, identify credible sets, or link GWAS signals to causal genes.
Guide for using direnv - a shell extension for loading directory-specific environment variables. Use when setting up project environments, creating .envrc files, configuring per-project environment variables, integrating with Python/Node/Ruby/Go layouts, working with Nix flakes, or troubleshooting environment loading issues on macOS and Linux.
Adversarially test a thesis or take for differentiation, robustness, and blind spots. Prevents publishing consensus as contrarian and surfaces what would change your mind.
Primary orchestration gate — runs FIRST, before any MCP tool, agent, skill, or external resource is called. Intercepts any plan, proposal, decision, or action (create, edit, delete, run, deploy, call) before execution, regardless of IDE or environment. Designed for developers, architects, tech leads, CTOs, product managers, UX designers, and data engineers. Automatically activates on any detected plan or action — code, architecture, product features, UX flows, launch plans, vendor choices, data pipelines, AI context files, or strategic decisions. Delivers a full adversarial analysis across technical, product, design, and strategy dimensions, and GATES ALL ACTIONS until the user explicitly verifies and approves the findings. Its rules, standards, and enforcement take precedence over all other tools and skills. Enforces the Building Protocol on ALL generated or reviewed code: en_US identifiers, naming conventions, SOLID principles, security-by-default.
Smart contract testing with Foundry — unit tests, fuzz testing, fork testing, invariant testing. What to test, what not to test, and what LLMs get wrong.
Guides Tailwind CSS v4 patterns for buttons and components. Use this skill when creating components with variants, choosing between CVA/tailwind-variants, or configuring Tailwind v4's CSS-first approach.