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Found 142 Skills
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
Use this skill when diagnosing, configuring, or monitoring NICs for AF_XDP / XDP workloads. Covers driver detection, hardware queue configuration, offload control (GSO/GRO/TSO/LRO), VLAN offloads, Flow Director (FDIR) rules, CPU core pinning and NUMA awareness, hardware queue and drop monitoring, BPF program inspection with bpftool, kernel tracing via ftrace, perf profiling and flamegraphs, IRQ-to-queue-to-core mapping, and a quick diagnostic checklist.
Assess chemical and drug toxicity via adverse outcome pathways, real-world adverse event signals, and toxicogenomic evidence. Integrates AOPWiki (AOPWiki_list_aops, AOPWiki_get_aop) for mechanism- level pathway tracing, FAERS for post-market adverse event quantification, OpenFDA for label mining, and CTD for chemical-gene-disease evidence. Produces structured toxicity reports with evidence grading (T1-T4). Use when asked about toxicity mechanisms, adverse outcome pathways, AOP mapping, FAERS signal detection, or chemical-disease relationships for drugs or environmental chemicals.
Use this skill when diagnosing, configuring, or monitoring NICs for AF_XDP / XDP workloads. Covers driver detection, hardware queue configuration, ring buffer sizing, RSS indirection table management, interrupt coalesce tuning, offload control (GSO/GRO/TSO/LRO), VLAN offloads, Flow Director (FDIR) rules with loc pinning and ixgbe wipe bug workaround, RPS/XPS queue CPU mapping, sysctl network tuning, CPU core pinning and NUMA awareness, hardware queue and drop monitoring, softirq and rx_missed_errors analysis, BPF program inspection with bpftool (prog dump xlated, net show), kernel tracing via ftrace and dmesg, perf profiling and flamegraphs, IRQ-to-queue-to-core mapping, bonding interface diagnostics, socket inspection, and a quick diagnostic checklist.
Use when designing a prospective clinical study before submission — selecting and classifying endpoints (primary / key-secondary / exploratory, with surrogate-endpoint flagging), estimating sample size and power for two-arm designs (means / proportions / survival), or scoring a study plan for feasibility and a GO / GO-WITH-CONDITIONS / REDESIGN / NO-GO phase-gate decision. Every output is an ESTIMATE plus a named human owner (clinician / biostatistician / regulatory owner) — never clinical fact, never a finished protocol. Distinct from ra-qm-team, which handles the regulatory/QM submission (ISO 13485, EU MDR, FDA 510(k)/PMA/QSR), not the study design.
Trading expert for Forex/CFD, indices (DAX, NASDAQ, S&P500), MQL5, Pine Script v5, MT5 Python API. Use for: trading strategies, technical analysis, risk management, Expert Advisors, custom indicators, backtesting, copy trading, prop trading rules, Smart Money Concepts, ICT, Ichimoku Kinko Hyo, ŚWISTAK Fibonacci.
Framework for computational fluid dynamics simulations using Python. Use when running fluid dynamics simulations including Navier-Stokes equations (2D/3D), shallow water equations, stratified flows, or when analyzing turbulence, vortex dynamics, or geophysical flows. Provides pseudospectral methods with FFT, HPC support, and comprehensive output analysis.
Generate AgentforcePlatformTracingSettings metadata to enable or disable Agentforce agent execution trace spans flowing to Data Cloud. Use this skill for any AgentforcePlatformTracingSettings metadata work. TRIGGER when: user mentions Agentforce tracing, agent trace spans, Data Cloud tracing, AgentforcePlatformTracingSettings, platform observability tracing, enable agent tracing, wants agent execution spans in Data Cloud, mentions .settings-meta.xml for AgentforcePlatformTracing, or asks about enabling observability for Agentforce agents. DO NOT TRIGGER when: user wants Platform Tracing for TraceSpanEvent (use platform-tracing-configure), wants to query or analyze existing agent trace data in Data Cloud (use agentforce-observe), wants Event Log Files or ELF configuration, wants Change Data Capture (use integration-eventing-cdc-configure), or wants ManagedEventSubscription (use integration-eventing-subscription-configure).
MUST activate when the project contains a uiBundles/*/src/ directory and the task involves creating or configuring a Custom Application for hosting a UI bundle in Lightning Experience. Use this skill when creating a CustomApplication metadata record to surface the UI bundle in the App Launcher. Activate when files matching applications/*.app-meta.xml exist and need modification, or when the user wants to expose their app via the Lightning App Launcher without a Digital Experience Site. Do NOT use platform-custom-application-generate for this — UI bundle apps do not use tabs, action overrides, or flexipages.
Generate EventSettings metadata to enable or disable Platform Tracing (TraceSpanEvent publishing) in Event Monitoring. Use this skill for any EventSettings enablePlatformTracing metadata work. TRIGGER when: user mentions Platform Tracing, TraceSpanEvent, enable tracing in Event Monitoring Settings, event monitoring tracing toggle, enablePlatformTracing, .settings-meta.xml for Event settings tracing, turn on trace span events, or stop publishing trace spans. DO NOT TRIGGER when: user wants Agentforce agent tracing to Data Cloud (use platform-tracing-agentforce-configure), wants Event Log Files or ELF generation, wants Change Data Capture (use integration-eventing-cdc-configure), or wants ManagedEventSubscription (use integration-eventing-subscription-configure).
MUST activate when the project contains a uiBundles/*/src/ directory and the task involves creating or configuring a Custom Application for hosting a UI bundle in Lightning Experience. Use this skill when creating a CustomApplication metadata record to surface the UI bundle in the App Launcher. Activate when files matching applications/*.app-meta.xml exist and need modification, or when the user wants to expose their app via the Lightning App Launcher without a Digital Experience Site. Do NOT use generating-custom-application for this — UI bundle apps do not use tabs, action overrides, or flexipages.
Performs fast file discovery with parallel search and smart defaults. Use this skill when searching for files by name, pattern, or type, especially when performance matters or when working with large directories