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Found 5,504 Skills
Comprehensive multi-omics disease characterization integrating genomics, transcriptomics, proteomics, pathway, and therapeutic layers for systems-level understanding. Produces a detailed multi-omics report with quantitative confidence scoring (0-100), cross-layer gene concordance analysis, biomarker candidates, therapeutic opportunities, and mechanistic hypotheses. Uses 80+ ToolUniverse tools across 8 analysis layers. Use when users ask about disease mechanisms, multi-omics analysis, systems biology of disease, biomarker discovery, or therapeutic target identification from a disease perspective.
Integrate and analyze multiple omics datasets (transcriptomics, proteomics, epigenomics, genomics, metabolomics) for systems biology and precision medicine. Performs cross-omics correlation, multi-omics clustering (MOFA+, NMF), pathway-level integration, and sample matching. Coordinates ToolUniverse skills for expression data (RNA-seq), epigenomics (methylation, ChIP-seq), variants (SNVs, CNVs), protein interactions, and pathway enrichment. Use when analyzing multi-omics datasets, performing integrative analysis, discovering multi-omics biomarkers, studying disease mechanisms across molecular layers, or conducting systems biology research that requires coordinated analysis of transcriptome, genome, epigenome, proteome, and metabolome data.
Perform statistical modeling and regression analysis on biomedical datasets. Supports linear regression, logistic regression (binary/ordinal/multinomial), mixed-effects models, Cox proportional hazards survival analysis, Kaplan-Meier estimation, and comprehensive model diagnostics. Extracts odds ratios, hazard ratios, confidence intervals, p-values, and effect sizes. Designed to solve BixBench statistical reasoning questions involving clinical/experimental data. Use when asked to fit regression models, compute odds ratios, perform survival analysis, run statistical tests, or interpret model coefficients from provided data.
Production-ready VCF processing, variant annotation, mutation analysis, and structural variant (SV/CNV) interpretation for bioinformatics questions. Parses VCF files (streaming, large files), classifies mutation types (missense, nonsense, synonymous, frameshift, splice, intronic, intergenic) and structural variants (deletions, duplications, inversions, translocations), applies VAF/depth/quality/consequence filters, annotates with ClinVar/dbSNP/gnomAD/CADD via ToolUniverse, interprets SV/CNV clinical significance using ClinGen dosage sensitivity scores, computes variant statistics, and generates reports. Solves questions like "What fraction of variants with VAF < 0.3 are missense?", "How many non-reference variants remain after filtering intronic/intergenic?", "What is the pathogenicity of this deletion affecting BRCA1?", or "Which dosage-sensitive genes overlap this CNV?". Use when processing VCF files, annotating variants, filtering by VAF/depth/consequence, classifying mutations, interpreting structural variants, assessing CNV pathogenicity, comparing cohorts, or answering variant analysis questions.
This rule enforces the Don't Repeat Yourself principle to avoid code duplication and improve maintainability.
Titanium SDK UI/UX patterns and components expert. Use when working with, reviewing, analyzing, or examining Titanium layouts, ListView/TableView performance optimization, event handling and bubbling, gestures (swipe, pinch), animations, accessibility (VoiceOver/TalkBack), orientation changes, custom fonts/icons, app icons/splash screens, or platform-specific UI (Action Bar, Navigation Bar).
Titanium Alloy MVC official framework reference. Use when working with, reviewing, analyzing, or examining Alloy models, views, controllers, Backbone.js data binding, TSS styling, widgets, Alloy CLI, sync adapters, migrations, or MVC compilation. Explains how Backbone.js models and collections work in Alloy.
Create and launch Solana tokens gasless on pump.fun via ClawPump. Swap SPL tokens via Jupiter, scan cross-DEX arbitrage on Raydium/Orca/Meteora, check agent fee earnings, view token leaderboard, search domains, and upload token images. Full Solana DeFi toolkit for AI agents — no gas, no wallet funding needed.
Guide for implementing HolmesGPT - an AI agent for troubleshooting cloud-native environments. Use when investigating Kubernetes issues, analyzing alerts from Prometheus/AlertManager/PagerDuty, performing root cause analysis, configuring HolmesGPT installations (CLI/Helm/Docker), setting up AI providers (OpenAI/Anthropic/Azure), creating custom toolsets, or integrating with observability platforms (Grafana, Loki, Tempo, DataDog).
Composable binary security suite for static analysis, dynamic tracing, contract capture, baseline drift, and policy gating. Triggers: "binary security", "reverse engineer binary", "black-box binary test", "behavioral trace", "baseline diff", "security suite".
Solve CTF binary exploitation challenges by discovering and exploiting memory corruption vulnerabilities to read flags. Use for buffer overflows, format strings, heap exploits, ROP challenges, or any pwn/exploitation task.
Sentry-specific security review based on real vulnerability history. Use when reviewing Sentry endpoints, serializers, or views for security issues. Trigger keywords: "sentry security review", "check for IDOR", "access control review", "org scoping", "cross-org", "security audit endpoint".