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Found 5,503 Skills
Use when asked to "thinking in bets", "make decisions under uncertainty", "think probabilistically", "avoid resulting", "separate decision quality from outcomes", or "reduce bias in decisions". Helps make explicit bets and evaluate decisions on process, not results. The Thinking in Bets framework (from Annie Duke) applies poker strategy to business and life decisions.
AI-driven patient-to-trial matching for precision medicine and oncology. Given a patient profile (disease, molecular alterations, stage, prior treatments), discovers and ranks clinical trials from ClinicalTrials.gov using multi-dimensional matching across molecular eligibility, clinical criteria, drug-biomarker alignment, evidence strength, and geographic feasibility. Produces a quantitative Trial Match Score (0-100) per trial with tiered recommendations and a comprehensive markdown report. Use when oncologists, molecular tumor boards, or patients ask about clinical trial options for specific cancer types, biomarker profiles, or post-progression scenarios.
Provide comprehensive clinical interpretation of somatic mutations in cancer. Given a gene symbol + variant (e.g., EGFR L858R, BRAF V600E) and optional cancer type, performs multi-database analysis covering clinical evidence (CIViC), mutation prevalence (cBioPortal), therapeutic associations (OpenTargets, ChEMBL, FDA), resistance mechanisms, clinical trials, prognostic impact, and pathway context. Generates an evidence-graded markdown report with actionable recommendations for precision oncology. Use when oncologists, molecular tumor boards, or researchers ask about treatment options for specific cancer mutations, resistance mechanisms, or clinical trial matching.
Search academic literature using Semantic Scholar, arXiv, and OpenAlex APIs. Returns structured JSONL with title, authors, year, venue, abstract, citations, and BibTeX. Use when the user needs to find papers, check related work, or build a bibliography.
Continuous repository security scanning and release gating. Triggers: "security scan", "security audit", "pre-release security", "run scanners", "check vulnerabilities".
React Native Reanimated 4.x animation patterns. Use when adding animations, transitions, entering/exiting effects, or gesture-driven animations to React Native screens. Replaces Framer Motion for mobile.
Integrate Cartridge Controller into native mobile applications (iOS, Android, React Native) and web wrappers (Capacitor). Use when building mobile games or apps that need Controller wallet functionality with local keypair signing. Covers SessionConnector for native auth flows, Controller.c FFI bindings, passkey configuration with Apple App Site Association, and platform-specific setup.
Setup Spanora AI observability in any project (JavaScript/TypeScript or Python). Use when user asks to "add spanora", "setup spanora", "integrate spanora", "add AI observability", "monitor LLM calls with spanora", "track AI costs", or mentions spanora in the context of adding observability to their project. Detects the language and installed AI SDKs (Vercel AI, Anthropic, OpenAI, LangChain) and configures the optimal integration pattern.
Analyze metabolomics data including metabolite identification, quantification, pathway analysis, and metabolic flux. Processes LC-MS, GC-MS, NMR data from targeted and untargeted experiments. Performs normalization, statistical analysis, pathway enrichment, metabolite-enzyme integration, and biomarker discovery. Use when analyzing metabolomics datasets, identifying differential metabolites, studying metabolic pathways, integrating with transcriptomics/proteomics, discovering metabolic biomarkers, performing flux balance analysis, or characterizing metabolic phenotypes in disease, drug response, or physiological conditions.
Production-ready phylogenetics and sequence analysis skill for alignment processing, tree analysis, and evolutionary metrics. Computes treeness, RCV, treeness/RCV, parsimony informative sites, evolutionary rate, DVMC, tree length, alignment gap statistics, GC content, and bootstrap support using PhyKIT, Biopython, and DendroPy. Performs NJ/UPGMA/parsimony tree construction, Robinson-Foulds distance, Mann-Whitney U tests, and batch analysis across gene families. Integrates with ToolUniverse for sequence retrieval (NCBI, UniProt, Ensembl) and tree annotation. Use when processing FASTA/PHYLIP/Nexus/Newick files, computing phylogenetic metrics, comparing taxa groups, or answering questions about alignments, trees, parsimony, or molecular evolution.
Comprehensive computational validation of drug targets for early-stage drug discovery. Evaluates targets across 10 dimensions (disambiguation, disease association, druggability, chemical matter, clinical precedent, safety, pathway context, validation evidence, structural insights, validation roadmap) using 60+ ToolUniverse tools. Produces a quantitative Target Validation Score (0-100) with GO/NO-GO recommendation. Use when users ask about target validation, druggability assessment, target prioritization, or "is X a good drug target for Y?"
Predict patient response to immune checkpoint inhibitors (ICIs) using multi-biomarker integration. Given a cancer type, somatic mutations, and optional biomarkers (TMB, PD-L1, MSI status), performs systematic analysis across 11 phases covering TMB classification, neoantigen burden estimation, MSI/MMR assessment, PD-L1 evaluation, immune microenvironment profiling, mutation-based resistance/sensitivity prediction, clinical evidence retrieval, and multi-biomarker score integration. Generates a quantitative ICI Response Score (0-100), response likelihood tier, specific ICI drug recommendations with evidence, resistance risk factors, and a monitoring plan. Use when oncologists ask about immunotherapy eligibility, checkpoint inhibitor selection, or biomarker-guided ICI treatment decisions.