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Found 1,762 Skills
Turn one core value proposition into genuinely distinct ad copy variants - headline, primary text, description, and CTA combinations - each labelled with angle, awareness stage, formula, and version so test results stay attributable. A real variant is a new angle, never a reworded line. Use whenever the user asks to write ad copy, needs headline or CTA variations, wants copy to A/B test, has ads that all sound the same, or needs a search ad headline set or an ML asset pool - even if they never say 'variants'. Covers B2B and B2C. Do NOT use for video or creator scripts (mbfinotti/advertising-skills@ugc-ad-scripts), a designer brief (mbfinotti/advertising-skills@ad-creative-brief), or test design (mbfinotti/advertising-skills@ad-creative-test-plan).
Compares actual spend and revenue against forecasts. Provides variance analysis and corrective insights to ensure financial discipline.
Analyze budget vs actual variances in Excel with drill-down and root cause analysis. Use when performing variance analysis or explaining budget differences. Trigger with phrases like 'excel variance', 'analyze budget variance', 'actual vs budget'.
Guides advanced long-term actuarial mathematics (SOA ALTAM)—survival models, life insurance and annuity APVs, premiums and reserves (equivalence principle, Thiele), multiple decrement and Markov states, yield-curve discounting, mortality improvement, longevity risk, profit testing, and mortality graduation. Tool-agnostic, concept-first. Use when the user mentions advanced long-term actuarial mathematics, ALTAM, survival model, life insurance reserve, annuity valuation, equivalence principle, Thiele equation, multiple decrement, force of mortality, longevity risk, mortality improvement, actuarial present value, or net premium reserve—not ASTAM/P&C (advanced-short-term-actuarial-mathematics), workpapers only (actuarial-analyst), appointed actuary (appointed-chief-actuary), assumption governance (assumption-setting), ALM detail (asset-liability-management), or exam-only deliverables.
Devil's Advocate stress-testing for code, architecture, PRs, and decisions. Surfaces hidden flaws through structured adversarial analysis with metacognitive depth. Use for high-stakes review, stress-testing choices, or when the user wants problems found deliberately. NOT for routine code review (use engineering:code-review). Triggers on "스트레스 테스트", "stress test", "devil's advocate", "반론", "이거 괜찮아", "문제 없을까", "깊은 리뷰", "critical review", "adversarial".
Production-ready VCF processing, variant annotation, mutation analysis, and structural variant (SV/CNV) interpretation for bioinformatics questions. Parses VCF files (streaming, large files), classifies mutation types (missense, nonsense, synonymous, frameshift, splice, intronic, intergenic) and structural variants (deletions, duplications, inversions, translocations), applies VAF/depth/quality/consequence filters, annotates with ClinVar/dbSNP/gnomAD/CADD via ToolUniverse, interprets SV/CNV clinical significance using ClinGen dosage sensitivity scores, computes variant statistics, and generates reports. Solves questions like "What fraction of variants with VAF < 0.3 are missense?", "How many non-reference variants remain after filtering intronic/intergenic?", "What is the pathogenicity of this deletion affecting BRCA1?", or "Which dosage-sensitive genes overlap this CNV?". Use when processing VCF files, annotating variants, filtering by VAF/depth/consequence, classifying mutations, interpreting structural variants, assessing CNV pathogenicity, comparing cohorts, or answering variant analysis questions.
Execute mcloud variables commands to list and get environment variables for a Cloud environment. Use when inspecting, reading, or exporting environment variables. Never pass --reveal unless the user explicitly requests secret values.
Write flux commentary for every P&L and balance-sheet line over threshold — current vs prior period and vs budget, with the driver explained from underlying activity. Use for the month-end close package and management reporting.
Review code through hostile perspectives to find bugs, security issues, and unintended consequences the author missed. Use when reviewing PRs, auditing codebases, or before critical deployments.
Germline and somatic short-variant calling pipeline for Illumina short-read data. Use when the user mentions BWA, BWA-MEM2, GATK, HaplotypeCaller, Mutect2, VCF, GVCF, VQSR, variant calling, germline, somatic, SNV, or indel calling from FASTQ/BAM.
Reason about germline and somatic variant classification using ACMG/AMP 2015 and AMP/ASCO/CAP frameworks. Use when the user asks to classify a variant, interpret a VCF annotation, resolve a VUS, apply ACMG criteria, weigh ClinVar evidence, evaluate gnomAD allele frequencies, interpret REVEL/CADD/SpliceAI scores, decide whether PVS1 applies, or assess gene-disease validity before reporting. Triggers include "ACMG", "variant classification", "pathogenic", "likely pathogenic", "VUS", "benign", "ClinVar", "gnomAD", "REVEL", "CADD", "SpliceAI", "PVS1", "loss of function", "nonsense variant", "missense interpretation", "splice variant", "filtering allele frequency", "ClinGen", "somatic variant tier".
Systematic ACMG/AMP variant classification using ToolUniverse tools. Given a genetic variant (HGVS, rsID, or gene+change), applies all 28 ACMG criteria (PVS1, PS1-4, PM1-6, PP1-5, BA1, BS1-4, BP1-7) through automated database queries and computational predictions. Produces a final 5-tier classification (Pathogenic / Likely Pathogenic / VUS / Likely Benign / Benign) with evidence summary. Use when asked to classify a variant, interpret a VUS, apply ACMG criteria, assess pathogenicity, or determine clinical significance of a germline variant.